Evidence map›Paper›PMID 40582639›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

Reproducibility of circumferential strain on cine displacement encoding with stimulated echoes magnetic resonance imaging before and after contrast at 3T.

Siyue Li, Shu-Fu Shih, Arutyun Pogosyan, Zhengyang Ming, Brian M Dale, Fei Han, J Paul Finn, Kim-Lien Nguyen, Xiaodong Zhong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Siyue LiDepartment of Radiological Sciences, University of California Los Angeles, Los Angeles, California, USA.
Shu-Fu ShihDepartment of Radiological Sciences, University of California Los Angeles, Los Angeles, California, USA.
Arutyun PogosyanDivision of Cardiology, University of California Los Angeles, Los Angeles, California, USA; Division of Cardiology, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA.
Zhengyang MingDepartment of Radiological Sciences, University of California Los Angeles, Los Angeles, California, USA; Physics and Biology in Medicine Graduate Program, University of California, Los Angeles, California, USA.
Brian M DaleMR R&D Collaborations, Siemens Medical Solutions USA, Inc., Cary, North Carolina, USA.
Fei HanMR R&D Collaborations, Siemens Medical Solutions USA, Inc., Los Angeles, California, USA.
J Paul FinnDepartment of Radiological Sciences, University of California Los Angeles, Los Angeles, California, USA; Physics and Biology in Medicine Graduate Program, University of California, Los Angeles, California, USA.
Kim-Lien NguyenDepartment of Radiological Sciences, University of California Los Angeles, Los Angeles, California, USA; Division of Cardiology, University of California Los Angeles, Los Angeles, California, USA; Division of Cardiology, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA; Physics and Biology in Medicine Graduate Program, University of California, Los Angeles, California, USA.
Xiaodong ZhongDepartment of Radiological Sciences, University of California Los Angeles, Los Angeles, California, USA; Physics and Biology in Medicine Graduate Program, University of California, Los Angeles, California, USA; Department of Bioengineering, University of California Los Angeles, Los Angeles, California, USA. Electronic address: xiaodongzhong@mednet.ucla.edu.

Funding

Ferumoxytol-Enhanced Cardiac MRI for Ischemic Heart DiseaseR01HL148182 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NGUYEN, KIM-LIEN T · 2020 to 2024
$3.8M
Cardiac MRI for Reperfusion Spatial Mapping to Improve Heart Failure OutcomesR01HL169695 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Kim-Lien T Nguyen · 2023 to 2026
$2.7M
CSRD VA I01 CX001901NHLBI NIH HHS R01 HL148182NHLBI NIH HHS R01 HL169695
6 · The paper itself

Abstract

backgroundMagnetic resonance imaging (MRI) with displacement encoding with stimulated echoes (DENSE) is well recognized for accurate and precise quantification of myocardial displacement and strain, but its reproducibility before and after contrast injection has not been investigated. Gadolinium is the most widely used contrast agent. Ferumoxytol is increasingly used off-label in specific patient groups. We aim to assess the reproducibility of cine DENSE MRI to measure global and segmental circumferential myocardial strain (E

methodsAll imaging was conducted using 3T scanners. In 11 patients with cardiac disease, breath-hold two-dimensional cine DENSE was acquired in a mid-ventricular short-axis slice before and following the injection of gadolinium (0.1 mmol/kg). A separate cohort of 11 subjects (5 healthy subjects and 6 patients with ischemic heart disease) received 3 incremental doses of ferumoxytol: 0.125, 1.875, and 2.0 mg/kg (to a cumulative dose of 4.0 mg/kg). The same DENSE acquisition was performed before and after each incremental dose. Post-processing generated left ventricular (LV) displacement and E

resultsBased on the percentage within the ROPE and the corresponding p-values, global E

conclusionGood reproducibility of global and segmental E

Indexed as

Contrast MediaFerrosoferric OxideHeart DiseasesMagnetic Resonance Imaging, CineMyocardial ContractionOrganometallic CompoundsVentricular Function, LeftAdultAgedBiomechanical PhenomenaBreath HoldingCase-Control StudiesFemaleHumansMaleMiddle AgedContrast MediaFerrosoferric OxideOrganometallic CompoundsCMRDENSEFerumoxytolGadoliniumMyocardial strain imagingReproducibility

Identifiers

PMID40582639
PMCPMC12785165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.