Evidence map›Paper›PMID 40582570›Full record

ArticleMucosal immunology2025

Single-cell RNA profiling identifies immune cell population shifts in diabetes associated mucosal inflammation.

Bushra Alghamdi, Min Liu, Xin Huang, Rahul Debnath, Hamideh Afzali, Michael Troka, Akira Hasuike, Quinn Easter, Mi Zhou, Kevin Byrd and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mucosal immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Bushra AlghamdiDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Restorative Dental Sciences, College of Dentistry, Taibah University, Medina, Kingdom of Saudi Arabia.
Min LiuDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Xin HuangHospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, China.
Rahul DebnathDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA; Faculty of Paramedical Sciences, Assam down town University, Assam, India.
Hamideh AfzaliDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Michael TrokaDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Akira HasuikeDepartment of Periodontology, Nihon University School of Dentistry, Tokyo, Japan.
Quinn EasterDepartment of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, VA, USA.
Mi ZhouDepartment of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Kevin ByrdDepartment of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, VA, USA.
Michael GonzalezCenter for Cytokine Storm Treatment & Laboratory, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kang I KoDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Dana T GravesDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: dtgraves@upenn.edu.

Funding

Diabetes-enhanced Experimental PeriodontitisR01DE017732 · NIDCR · UNIV OF MED/DENT OF NJ-NJ DENTAL SCHOOL · PI DANA T GRAVES · 2007 to 2026
$6.5M
Mechanisms for Impaired Diabetic Wound HealingR01DE019108 · NIDCR · UNIV OF MED/DENT OF NJ-NJ DENTAL SCHOOL · PI DANA T GRAVES · 2009 to 2026
$4.8M
Dendritic Cells and Periodontal DiseaseR01DE021921 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI GRAVES, DANA T · 2012 to 2022
$4.2M
Diabetes reversal and the subgingival microbiotaR01DE026603 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI GRAVES, DANA T, GRIFFEN, ANN L · 2018 to 2022
$2.4M
Regulation of epithelial barrierR01DE031046 · NIDCR · GEORGETOWN UNIVERSITY · PI ALIMPERTI, STELLA, GRAVES, DANA T · 2021 to 2025
$2.3M
MECHANISMS OF PERIODONTAL DESTRUCTIONR01DE011254 · NIDCR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GRAVES, DANA T · 1995 to 2002
$882k
NIDCR NIH HHS R01 DE011254NIDCR NIH HHS R01 DE017732NIDCR NIH HHS R01 DE019108NIDCR NIH HHS R01 DE021921NIDCR NIH HHS R01 DE026603NIDCR NIH HHS R01 DE031046
6 · The paper itself

Abstract

Poorly controlled diabetes significantly worsens periodontal disease, affecting millions worldwide, yet the mechanisms driving this destructive synergy remain unclear. We generated single-cell RNA sequencing profiles of diabetic periodontal tissue, revealing increased γ

Indexed as

Diabetes Mellitus, ExperimentalInflammationNeutrophilsPeriodontitisT-Lymphocytes, RegulatoryAnimalsDisease Models, AnimalFemaleGene Expression ProfilingHumansImmunity, MucosalMaleMiceMice, Inbred C57BLReceptors, Antigen, T-Cell, gamma-deltaSingle-Cell AnalysisReceptors, Antigen, T-Cell, gamma-deltaGene expressionHyperglycemiaImmune cellsOral microbiomePeriodontitisTranscriptomics

Identifiers

PMID40582570
PMCPMC12766642

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.