Evidence map›Paper›PMID 40582412›Full record

ArticleVirologica Sinica2025

Identification of PEDV inhibitors targeting 3CL protease.

Ang Tian, Shutong Shi, Siying Zou, Shuaiyin Guan, Hao Wu, Zhen Li, Huanchun Chen, Yunfeng Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virologica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ang TianCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.
Shutong ShiCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.
Siying ZouCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.
Shuaiyin GuanCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.
Hao WuCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.
Zhen LiCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.
Huanchun ChenCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.
Yunfeng SongCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China. Electronic address: syf@mail.hzau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Porcine epidemic diarrhea (PED), caused by porcine epidemic diarrhea virus (PEDV), is a highly contagious gastrointestinal disease characterized by vomiting, diarrhea, and dehydration, with mortality rates approaching 100% among suckling piglets. The PEDV 3C-like protease (3CLpro) is essential for viral replication and regarded as a critical target for antiviral inhibitor development. In this study, we aimed to identify small-molecule inhibitors of PEDV by targeting 3CLpro. Virtual screening of 1.6 million compounds from the ChemDiv library identified four potential candidates. Molecular dynamics simulations, specifically analyzing RMSD, RMSF, and Rg, demonstrated increased structural stability of the compound-protease complexes compared to the monomeric enzyme. All compounds had low cytotoxicity in Vero cells (CC

Indexed as

Antiviral AgentsCoronavirus 3C ProteasesPorcine epidemic diarrhea virusProtease InhibitorsAnimalsChlorocebus aethiopsMolecular Docking SimulationMolecular Dynamics SimulationSwineVero CellsVirus ReplicationAntiviral AgentsCoronavirus 3C ProteasesProtease Inhibitors3CL proteaseAntiviralPorcine epidemic diarrhea virus (PEDV)Virtual screening

Identifiers

PMID40582412
PMCPMC12414381

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.