Evidence map›Paper›PMID 40582407›Full record

ArticleJournal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer2025

Clinical and Pathologic Phenotyping of Mesotheliomas Developing in Carriers of Germline BAP1 Mutations.

Michele Carbone, Michael Minaai, Muaiad Kittaneh, Thomas Krausz, Markku M Miettinen, Qiang Pan Hammarström, Lennart Hammarström, Hassan Abolhassani, Ian Pagano, Ronghui Xu and 8 more

Abstract read
In one paragraph

Article in Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Moving Beyond Morphology: Toward a Morpho-Molecular Classification of Pleural Mesothelioma.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2026
    Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Advances in the Basic Sciences in Thoracic Oncology in the Last 20 Years and Their Translational Impact.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2026
    Review
  14. Review
  15. Prospective Analysis of Mesotheliomas in Subjects With BAP1 Cancer Syndrome: Clinical Characteristics and Epigenetic Correlates of Disease.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2025
    Observational
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Michele CarboneThoracic Oncology Program, University of Hawaii Cancer Center, Honolulu, Hawaii. Electronic address: mcarbone@cc.hawaii.edu.
Michael MinaaiThoracic Oncology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Muaiad KittanehDrug Development Service, ICON Clinical Research, Chicago, Illinois.
Thomas KrauszDepartment of Pathology, University of Chicago, Chicago, Illinois.
Markku M MiettinenLaboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Qiang Pan HammarströmDivision of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
Lennart HammarströmDivision of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
Hassan AbolhassaniDivision of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
Ian PaganoThoracic Oncology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Ronghui XuThoracic Oncology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Flavia NovelliThoracic Oncology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Giovanni GaudinoThoracic Oncology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Sandra PastorinoThoracic Oncology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Kavita Y SarinDepartment of Dermatology, Stanford University, Stanford, California.
Robert T RipleyDavid J. Sugarbaker Division of Thoracic Surgery, Michael E. DeBakey Department of Surgery Baylor College of Medicine, Houston, Texas.
Harvey I PassDepartment of Cardiothoracic Surgery, New York University, New York, New York.
David S SchrumpThoracic Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Haining YangThoracic Oncology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.

Funding

University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Pallav Pokhrel · 1996 to 2026
$56.2M
The EDRN Mesothelioma Biomarker Discovery LaboratoryU01CA214195 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PASS, HARVEY IRA, YANG, HAINING · 2016 to 2021
$3.5M
Mechanisms of BAP1 activity in human cancer developmentR01CA237235 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI CARBONE, MICHELE, YANG, HAINING · 2020 to 2024
$2.1M
Targeting the Mitochondria to Overcome Resistance to Immune Checkpoint Inhibition in Malignant Pleural MesotheliomaR37CA289419 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Robert Taylor Ripley · 2024 to 2026
$2.0M
Influence of germline mutations on susceptibility to environmental carcinogensR01ES030948 · NIEHS · UNIVERSITY OF HAWAII AT MANOA · PI CARBONE, MICHELE, GRZYMSKI, JOSEPH J · 2019 to 2021
$1.9M
Germline BAP1 Mutations and Malignant Mesothelioma: Mechanisms and Early DetectionR01CA198138 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI CARBONE, MICHELE · 2015 to 2019
$1.7M
Novel strategies to improve mesothelioma therapyR01CA290173 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI MICHELE CARBONE, Robert Taylor Ripley · 2024 to 2026
$1.6M
NCI NIH HHS P30 CA071789NCI NIH HHS R01 CA198138NCI NIH HHS R01 CA237235NCI NIH HHS R01 CA290173NCI NIH HHS R37 CA289419NCI NIH HHS U01 CA214195NIEHS NIH HHS R01 ES030948
6 · The paper itself

Abstract

introductionMesothelioma is frequent among carriers of inactivating heterozygous germline BAP1 mutations (BAP1

methodsDuring 1999 to 2024, we studied 47 families carrying BAP1

resultsWe identified 34 different germline inactivating mutations. Among 238 BAP1

conclusionsCompared with sporadic mesotheliomas, mesotheliomas developing in BAP1

Indexed as

Germ-Line MutationLung NeoplasmsMesotheliomaTumor Suppressor ProteinsUbiquitin ThiolesteraseAdultAgedAged, 80 and overFemaleHeterozygoteHumansMaleMesothelioma, MalignantMiddle AgedPedigreePhenotypeBAP1 protein, humanTumor Suppressor ProteinsUbiquitin ThiolesteraseBAP1DiagnosisMesotheliomaPrognosis

Identifiers

PMID40582407
PMCPMC12303596

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.