ReviewCardiorenal medicine2025
Mechanisms of Congestion in Acute Decompensated Heart Failure.
Review in Cardiorenal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Dyspnea in heart failure: pathophysiology, clinical assessment, and evidence from clinical trials.Heart failure reviews · 2026Review
- Cardiorenal Interactions in Acute Decompensated Heart Failure: Associations Between Renal Dysfunction, Albuminuria, and Echocardiographic Markers of Myocardial Function.Life (Basel, Switzerland) · 2026Article
- Acute Kidney Injury in Acute Heart Failure Revisited: Marker of Cardiorenal Disease Severity Rather Than Isolated Renal Injury.Life (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute decompensated heart failure (ADHF) poses a challenging paradox of renal and cardiac pathophysiology, with volume excess or "congestion" being a key player. Understanding the mechanisms of congestion is crucial for effectively managing fluid overload and improving patient prognosis. SUMMARY: In this review, we evaluate the physiology of congestion and explore its implications for management in clinical practice. Mechanisms of congestion can largely be broken down under the subtext of fluid accumulation and fluid redistribution. Fluid accumulation develops as a consequence of neurohormonal dysregulation, physiologic maladaptive mechanisms, and detrimental crosstalk between the heart and the kidney. On the other hand, fluid redistribution evolves due to progressive overriding of compensatory vascular mechanisms, renal injury, and hormonal feedback. KEY MESSAGES: Understanding the complex pathophysiology of congestion in ADHF is crucial for effective volume management and protection against long-term mortality and morbidity risks. By targeting both fluid accumulation and redistribution mechanisms, clinicians can optimize treatment strategies to alleviate congestion and restore hemodynamic stability in patients with ADHF.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.