Evidence map›Paper›PMID 40582234›Full record

ArticleInternational journal of hygiene and environmental health2025

Carbaryl use and incident cancer in the Agricultural Health Study: an updated analysis.

Patricia A Erickson, Gabriella Andreotti, Richard V Remigio, Mary H Ward, Christine G Parks, Dale P Sandler, Paul S Albert, Kathryn Hughes Barry, Jonathan N Hofmann, Laura E Beane Freeman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of hygiene and environmental health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Patricia A EricksonOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA; Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Gabriella AndreottiOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Richard V RemigioOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Mary H WardOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Christine G ParksEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA.
Dale P SandlerEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA.
Paul S AlbertBiostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Kathryn Hughes BarryDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA; Program in Oncology, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.
Jonathan N HofmannOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Laura E Beane FreemanOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA. Electronic address: freemala@mail.nih.gov.

Funding

Studies of Occupational Cancer (Pesticides)ZIACP010119 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI BEANE FREEMAN, LAURA · 2009 to 2025
$46.1M
STUDIES OF OCCUPATIONAL CANCER--PESTICIDESZ01CP010119 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ALAVANJA, MICHAEL · 1996 to 2008
$5.0M
HEALTH EFFECTS OF EXPOSURES IN AGRICULTUREZ01ES049030 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 1997 to 2008
$889k
Epigenomic and transcriptomic markers of aggressive prostate cancer among African American menK07CA230182 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI BARRY, KATHRYN HUGHES · 2018 to 2023
$827k
Intramural NIH HHS Z01 CP010119Intramural NIH HHS Z01 ES049030Intramural NIH HHS ZIA CP010119NCI NIH HHS K07 CA230182
6 · The paper itself

Abstract

Carbaryl is a common carbamate insecticide in the United States (USA). Previous epidemiologic investigations, including within the Agricultural Health Study (AHS), have suggested potential associations between carbaryl use and cancer risk. The AHS is a prospective cohort study of licensed pesticide applicators in North Carolina (NC) and Iowa (IA), USA. Information on lifetime pesticide use was reported at enrollment (1993-1997) and follow-up (1999-2005). We evaluated cancer risks associated with ever- and intensity-weighted lifetime days (IWLD) of carbaryl use. Among 52,625 applicators, 8713 incident cancer cases were identified from linkages with state cancer registries through 2014 (NC) or 2017 (IA). We used Poisson regression to estimate rate ratios (RR) and 95 % confidence intervals (CI), controlling for confounders, and evaluated lagged exposures. Approximately 51 % of applicators reported using carbaryl. Increasing IWLD of carbaryl use was associated with increased stomach cancer risk (third tertile vs. never use; RR

Indexed as

CarbarylInsecticidesNeoplasmsOccupational ExposureAdultAgedFemaleHumansIncidenceIowaMaleMiddle AgedNorth CarolinaProspective StudiesCarbarylInsecticidesAgricultureCancerCarbarylOccupational exposurePesticides

Identifiers

PMID40582234
PMCPMC12306554

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.