ArticleJournal of chromatography. B, Analytical technologies in the biomedical and life sciences2025
Comprehensive pharmacokinetics and ADME evaluation of Akuamma alkaloids.
Article in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Indole Alkaloids as Biased Opioid Receptor Modulators.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Discovery of CRBN-recruiting PROTAC degraders of the METTL3-METTL14 complex.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2025Article
Corrections and comments
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Authors and funding
4 authors.
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Abstract
The seeds of the akuamma tree (Picralima nitida) have been traditionally used to treat fever and pain. The seed contains at least five major alkaloids: akuammine, akuammicine, akuammiline, picraline, and pseudo-akuammigine, which possess diverse pharmacological effects, including analgesic, anti-inflammatory, and mood-enhancing properties. The present study aimed to assess in vitro and in vivo pharmacokinetics of akuamma alkaloids using a sensitive ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)-based bioanalytical method. The method was found to be simple, sensitive, and rapid, effectively evaluating absorption, distribution, metabolism, and oral/intravenous pharmacokinetics in male Sprague-Dawley rats. These alkaloids demonstrated high permeability using human colorectal adenocarcinoma cell monolayers. Akuammine and akuammiline showed half-lives of 13.5 and 30.3 min in reduced nicotinamide adenine dinucleotide phosphate-supplemented rat liver microsomes. Pseudo-akuammigine showed the highest plasma protein binding, followed by the other alkaloids. Oral dosing of the ground seed suspension revealed significant systemic exposure of only akuammine, with low oral bioavailability. This research is the first comprehensive report on the ADME properties and pharmacokinetics of akuamma alkaloids, providing critical insights for developing these compounds as potential phytotherapeutic agents for pain management or other medicinal uses.
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Registered trials
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