Evidence map›Paper›PMID 40582157›Full record

ArticlePoultry science2025

Effect of guanidinoacetic acid on the growth performance, serum biochemical indices and metabolites, intestinal morphology, and intestinal flora of Cherry Valley broiler ducks.

Hongjiao Wang, Long Li, Xuefeng Yuan, Liang Hong, Lei Pu, Shunyi Qin, Liuan Li, Hua Yang, Jianbin Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Poultry science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hongjiao WangTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, 300392, China.
Long LiTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, 300392, China.
Xuefeng YuanTianjin Key Laboratory of Green Ecological Feed, Bao Di, Tianjin, China.
Liang HongTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, 300392, China.
Lei PuTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, 300392, China.
Shunyi QinTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, 300392, China.
Liuan LiTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, 300392, China.
Hua YangTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, 300392, China.
Jianbin ZhangTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, 300392, China. Electronic address: zjbzwz@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Guanidinoacetic acid (GAA) is a direct precursor for creatine synthesis in animals. Because of its great biological value and chemical stability, it can be used as a feed ingredient. The aim of this study was to investigate the effects of GAA on the growth performance, serum biochemical indices and metabolites, intestinal morphology, and intestinal flora of Cherry Valley broiler ducks. The growth performance of broiler ducks in the treatment group was significantly higher than that in the control group. Alanine aminotransferase and total protein were significantly lower in the treatment group than in the control group, while high-density lipoprotein and immunoglobulin A were significantly higher in the treatment group than in the control group. The gut microbial community richness was higher in the treatment group. There were 149 metabolites found in all. The most important pathways through which GAA influences the serum of broiler ducks are fatty acid degradation, Cushing syndrome, fat digestion and absorption, cortisol synthesis and secretion, lipid accumulation and atherosclerosis, alpha-linolenic acid metabolism, and the folate biosynthesis metabolic pathway, according to an enrichment analysis of metabolic pathways. Spearman's correlation analysis showed that microorganisms were closely associated with metabolites. In summary, adding GAA to the diet of Cherry Valley broiler ducks can enhance their growth performance, improve intestinal villi formation, improve digestion and absorption, boost immunoglobulin secretion, and improve immune function. It also optimises lipid metabolism and reduces the burden on the liver, promoting efficient energy utilisation and anti-inflammatory and antioxidant properties. Additionally, GAA alters the blood metabolites and cecal flora of Cherry Valley broiler ducks.

Indexed as

DucksGastrointestinal MicrobiomeGlycineIntestinesAnimal FeedAnimalsDietDietary SupplementsMaleRandom AllocationGlycineglycocyamineGrowth performanceGuanidinoacetic acidIntestinal morphology and intestinal floraSerum biochemical indices and metabolites

Identifiers

PMID40582157
PMCPMC12266509

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.