Evidence map›Paper›PMID 40582081›Full record

Observational studyJournal of psychiatric research2025

Pre-trauma insomnia and posttraumatic alcohol and cannabis use in the AURORA observational cohort study of trauma survivors.

Nicole A Short, Robyn A Ellis, Mattea Pezza, Stacey L House, Francesca L Beaudoin, Xinming An, Gari D Clifford, Tanja Jovanovic, Sarah D Linnstaedt, Scott L Rauch and 25 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of psychiatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Nicole A ShortDepartment of Psychology, University of Nevada, Las Vegas, NV, 89154, USA. Electronic address: nicole.short@unlv.edu.
Robyn A EllisDivision of Alcohol, Drugs, & Addiction, McLean Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Mattea PezzaDepartment of Psychology, University of Nevada, Las Vegas, NV, 89154, USA.
Stacey L HouseDepartment of Emergency Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Francesca L BeaudoinDepartment of Epidemiology, Brown University, Providence, RI, 02930, USA; Department of Emergency Medicine, Brown University, Providence, RI, 02930, USA.
Xinming AnInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA; Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA.
Gari D CliffordDepartment of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, 30332, USA; Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA.
Tanja JovanovicDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, 48202, USA.
Sarah D LinnstaedtInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA; Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA.
Scott L RauchInstitute for Technology in Psychiatry, McLean Hospital, Belmont, MA, 02478, USA; Department of Psychiatry, McLean Hospital, Belmont, MA, 02478, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, 02115, USA.
John P HaranDepartment of Emergency Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01655, USA.
Alan B StorrowDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Christopher LewandowskiDepartment of Emergency Medicine, Henry Ford Health System, Detroit, MI, 48202, USA.
Paul I MuseyDepartment of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Phyllis L HendryDepartment of Emergency Medicine, University of Florida College of Medicine -Jacksonville, Jacksonville, FL, 32209, USA.
Sophia SheikhDepartment of Emergency Medicine, University of Florida College of Medicine -Jacksonville, Jacksonville, FL, 32209, USA.
Christopher W JonesDepartment of Emergency Medicine, Cooper Medical School of Rowan University, Camden, NJ, 08103, USA.
Brittany E PunchesDepartment of Emergency Medicine, Ohio State University College of Medicine, Columbus, OH, 43210, USA; Ohio State University College of Nursing, Columbus, OH, 43210, USA.
Lauren A HudakDepartment of Emergency Medicine, Emory University School of Medicine, Atlanta, GA, 30329, USA.
Jose L PascualDepartment of Surgery, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, 19104, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Mark J SeamonPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA; Department of Surgery, Division of Traumatology, Surgical Critical Care and Emergency Surgery, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Claire PearsonDepartment of Emergency Medicine, Wayne State University, Ascension St. John Hospital, Detroit, MI, 48236, USA.
David A PeakDepartment of Emergency Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA; Department of Emergency Medicine, Harvard Medical School, Boston, MA, 02115, USA.
Roland C MerchantDepartment of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Robert M DomeierDepartment of Emergency Medicine, Trinity Health-Ann Arbor, Ypsilanti, MI, 48197, USA.
Niels K RathlevDepartment of Emergency Medicine, University of Massachusetts Medical School-Baystate, Springfield, MA, 01107, USA.
Brian J O'NeilDepartment of Emergency Medicine, Wayne State University, Detroit Receiving Hospital, Detroit, MI, 48202, USA.
Leon D SanchezDepartment of Emergency Medicine, Harvard Medical School, Boston, MA, 02115, USA; Department of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Steven E BruceDepartment of Psychological Sciences, University of Missouri - St. Louis, St. Louis, MO, 63121, USA.
Steven E HarteDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA; Department of Internal Medicine-Rheumatology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Ronald C KesslerDepartment of Health Care Policy, Harvard Medical School, Boston, MA, 02115, USA.
Karestan C KoenenDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, 02115, USA.
Kerry J ResslerDepartment of Psychiatry, Harvard Medical School, Boston, MA, 02115, USA; Division of Depression and Anxiety, McLean Hospital, Belmont, MA, 02478, USA.
Samuel A McLeanInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA; Department of Emergency Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA.
Thomas C NeylanDepartments of Psychiatry and Neurology, University of California San Francisco, San Francisco, CA, 94143, USA.

Funding

Longitudinal Assessment of Post-traumatic SyndromesU01MH110925 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KESSLER, RONALD C, KOENEN, KARESTAN C · 2016 to 2020
$25.8M
Extracellular vesicles as biomarkers of trauma exposure and PTSD riskR01MH129495 · NIMH · UNIVERSITY OF COLORADO DENVER · PI Tracy L Bale, Tanja Jovanovic · 2022 to 2026
$4.0M
Development of a digital therapeutic targeting anxiety sensitivity to reduce PTSD-SUD in women presenting for emergency care after sexual assault.K23DA054299 · NIDA · UNIVERSITY OF NEVADA LAS VEGAS · PI Nicole Amai Short · 2023 to 2026
$631k
NIDA NIH HHS K23 DA054299NIMH NIH HHS R01 MH129495NIMH NIH HHS U01 MH110925
6 · The paper itself

Abstract

BACKGROUND AND

aimsInsomnia symptoms are a potential risk factor for alcohol and cannabis use, particularly in trauma-exposed populations. The initial weeks and months after trauma are a period of risk for problematic substance use, however prior research has not examined whether insomnia symptoms predict alcohol or cannabis use after trauma.

designUsing a large-scale, multi-site, prospective study of trauma survivors presenting to emergency departments (EDs), the current study tested direct and indirect associations between pre-trauma insomnia symptoms, two-week posttraumatic stress disorder (PTSD) symptoms, and eight-week post-trauma heavy alcohol and cannabis use and binge drinking.

settingParticipants were recruited from 23 EDs in the United States and followed up using remote assessments. PARTICIPANTS/CASES: Participants were from the AURORA study (n = 2449). A slight majority were women (63.8 %) and were an average of 37 years old. Participants were racially and ethnically diverse (50.5 % Black, 11.2 % Hispanic). MEASUREMENTS: Participants completed self-report measures during their ED visit, and two- and eight-weeks post-trauma.

findingsPre-trauma insomnia symptoms significantly predicted eight-week post-trauma heavy alcohol and cannabis use, as well as binge drinking. Associations persisted after covarying for pre-trauma substance use, demographic variables, and trauma severity at the time of emergency care. Further, the association between pre-trauma insomnia symptoms and heavy alcohol and cannabis use at eight-weeks post-trauma was significantly mediated by two-week PTSD symptoms.

conclusionsInsomnia symptoms may be an important malleable risk factor for heavy alcohol and cannabis use and binge drinking after trauma. Further research is needed to explore the effectiveness of insomnia interventions to mitigate post-trauma substance use and to better understand the complex relationships between sleep, trauma, PTSD, and substance use.

Indexed as

AlcoholismBinge DrinkingMarijuana UseSleep Initiation and Maintenance DisordersStress Disorders, Post-TraumaticSurvivorsAdultCohort StudiesEmergency Service, HospitalFemaleHumansMaleMiddle AgedProspective StudiesUnited StatesYoung AdultAlcoholBinge drinkingCannabisInsomniaPosttraumatic stress disorder

Identifiers

PMID40582081
PMCPMC12228536

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.