Evidence map›Paper›PMID 40582054›Full record

ArticleUltrasonics sonochemistry2025

A novel ultrasound-responsive cluster bomb system for efficient siRNA delivery in brain.

Tianyu Guo, Feihong Dong, Jingyi Yin, Xinnan Wang, Pengting Min, Jiabin Zhang, Heping Cheng, Jue Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasonics sonochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Exosome-mediated siRNA delivery in cancer: Loading strategies, targeting approaches, and therapeutic outcomes.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tianyu GuoState Key Laboratory of Membrane Biology, National Biomedical Imaging Center, Peking-Tsinghua Center for Life Sciences, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing 100871, China.
Feihong DongState Key Laboratory of Membrane Biology, National Biomedical Imaging Center, Peking-Tsinghua Center for Life Sciences, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing 100871, China. Electronic address: dongfeihong_tjpu@163.com.
Jingyi YinAcademy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.
Xinnan WangAcademy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.
Pengting MinAcademy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.
Jiabin ZhangState Key Laboratory of Membrane Biology, National Biomedical Imaging Center, Peking-Tsinghua Center for Life Sciences, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing 100871, China.
Heping ChengState Key Laboratory of Membrane Biology, National Biomedical Imaging Center, Peking-Tsinghua Center for Life Sciences, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing 100871, China; National Biomedical Imaging Center, Peking University, Beijing 100871, China; Research Unit of Mitochondria in Brain Diseases, Chinese Academy of Medical Sciences, PKU-Nanjing Institute of Translational Medicine, Nanjing 211899, China.
Jue ZhangAcademy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China; College of Engineering, Peking University, Beijing 100871, China; National Biomedical Imaging Center, Peking University, Beijing 100871, China. Electronic address: zhangjue@pku.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RNA-based therapeutics using RNA interference have become a research hotspot for brain tumors and neurodegenerative diseases with the advancement of nanocarrier delivery technology. However, even with specific modifications, RNA-loaded nanoparticles face significant challenges in effectively crossing the blood-brain barrier (BBB) to achieve precise delivery of therapeutic agents to the brain. Focused ultrasound combined with microbubbles and nanodroplets has emerged as a promising approach for temporarily opening the BBB. However, the low drug loading capacity and fixed stimulation focus of these methods limit their integration with current nano-drug delivery systems. Herein, we introduced a fluorinated surfactant and developed an ultrasound-responsive siRNA delivery carrier that contains nanodroplets loaded with siRNA-carrying nanoparticles (siRNA@NP@ND), termed as "ultrasound-responsive 'cluster bomb' nanoplatform". Under precise and flexible guidance and stimulation through a programmable diagnostic ultrasound, siRNA@NP@ND demonstrated over a seventy-fold increase in efficiency for delivering siRNA to the mouse brain. Additionally, Evans blue staining and hematological analysis indicated that ultrasound-triggered cavitation could reversibly open the BBB for up to 48 h without causing significant immune or inflammatory responses. The minor intracranial hemorrhage resulting from this process was also shown to be recoverable. Our research provides an advanced and controllable delivery platform for gene therapy of intracranial central nervous system diseases.

Indexed as

BrainRNA, Small InterferingUltrasonic WavesAnimalsBlood-Brain BarrierMiceNanoparticlesRNA, Small InterferingBlood-brain barrierGene drugNanodropletsNanoparticlesUltrasound

Identifiers

PMID40582054
PMCPMC12268195

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.