ArticleMacromolecular bioscience2025
Fabrication of Lithium/Strontium-Releasing Smart Bioactive Glasses with Anti-Inflammatory and Osteogenic Effects Tailored to Pathological Stages.
Article in Macromolecular bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Modulation of bone homeostasis by dual drug-loaded premixed magnesium tri-magnesium phosphate bone cement for the treatment of osteoporotic vertebral compression fractures.Bioactive materials · 2025Article
- Fabrication of Lithium/Strontium-Releasing Smart Bioactive Glasses with Anti-Inflammatory and Osteogenic Effects Tailored to Pathological Stages.Macromolecular bioscience · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Bioactive glasses (BGs) are highly biocompatible with affinity for hard tissues and exhibit high bioactivity through ion release. Smart BGs that allow controlled ion release are required because uncontrolled release can lead to unexpected adverse effects on tissue regeneration. Strontium promotes osteoblast differentiation of mesenchymal stem cells (MSCs) and inhibits osteoclast activity. In this study, the release profile of strontium is regulated by the incorporation of aluminum into a phosphate-based BG. Furthermore, composites of strontium-releasing BG and lithium-releasing BG (Li/Sr-BG) show stepwise ion release, with rapid lithium release followed by sustained strontium release. Li/Sr-BG increases the expression of osteogenic markers and mineral deposition in MSCs, but suppresses osteoclast maturation, including multinucleation and osteoclast marker expression. Additionally, application of Li/Sr-BG to inflammatory macrophages decreases phagocytic activity and inflammatory gene expression, while increasing the expression of anti-inflammatory markers. Analysis of signaling proteins reveals that osteogenic and anti-inflammatory effects of Li/Sr-BG are attributed to the release of strontium and lithium, respectively. This study demonstrates that Li/Sr-BGs can be used for the development of novel smart bioactive materials that effectively suppress inflammation and promote bone formation in a manner that follows the process of bone regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.