ArticleAlimentary pharmacology & therapeutics2025
Prevalence and Predictors of Symptoms of Anxiety or Depression at Diagnosis in Patients With Inflammatory Bowel Disease: An Inception Cohort.
Article in Alimentary pharmacology & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gut microbiota alterations associated with anxiety and depression in inflammatory bowel disease: a systematic review of prospective cohorts and randomized trials.Frontiers in microbiology · 2026Pooled it
- Anxiety and depression in newly diagnosed patients with inflammatory bowel disease (the IBSEN III study) compared with the general population in Norway.Journal of Crohn's & colitis · 2026Article
- The Gut-Brain Axis in Comorbidity of Inflammatory Bowel Disease and Anxiety/Depression: Mechanisms, Controversies, and Future Directions.International journal of general medicine · 2026Review
- Depression and anxiety in inflammatory bowel disease: mechanisms and emerging therapeutics targeting the microbiota-gut-brain axis.Frontiers in immunology · 2025Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prevalence of symptoms of a common mental disorder, including anxiety or depression, is high among patients with established inflammatory bowel disease (IBD). This may represent a therapeutic target for affected patients. However, whether these symptoms arise from genuine gut-brain effects, or are merely a consequence of a preceding adverse disease course is unclear.
aimsTo assess prevalence and predictors of anxiety and depression in an inception cohort of patients with IBD.
methodsWe collected demographic data, disease-related information, diagnosis of a pre-existing common mental disorder, symptoms of a common mental disorder, using the hospital anxiety and depression score, and gastrointestinal symptom-specific anxiety, using the Visceral Sensitivity Index (VSI), from individuals newly diagnosed with IBD during their index outpatient appointment or inpatient admission. The prevalence of symptoms of a common mental disorder at diagnosis, and predictors of the presence of these symptoms, were examined.
resultsOf 300 participants, 117 (39.0%) reported symptoms of a common mental disorder (107 (35.7%) anxiety, 47 (15.7%) depression). Younger age, female sex, tobacco use, a longer duration of symptoms prior to diagnosis, higher gastrointestinal symptom-specific anxiety, and stressful life events in the preceding 12 months were associated with a significantly increased likelihood of reporting these symptoms. Higher gastrointestinal symptom-specific anxiety remained significant following logistic regression (OR 2.19; 95% CI 1.00-4.79 for VSI moderate and OR 13.5; 95% CI 5.86-31.2 for VSI high, p < 0.001 for trend).
conclusionPoor psychological health is highly prevalent at the time of an IBD diagnosis, suggesting genuine gut-brain effects.
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