Evidence map›Paper›PMID 40581885›Full record

ArticleNeuroscience bulletin2025

Multimodal Magnetic Resonance Imaging with Mild Repetitive Head Injury in Awake Rats: Modeling the Human Experience and Clinical Condition.

Nicole Bens, Arnold Chang, Richard Ortiz, Joshua Leaston, Praveen Kulkarni, Rosemarie Hightower, Sophia Prom, Nicholas O'Hare, Eno Ebong, Craig F Ferris

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience bulletin, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nicole BensCenter for Translational Neuroimaging, Northeastern University, Boston, MA, 02115, USA.
Arnold ChangCenter for Translational Neuroimaging, Northeastern University, Boston, MA, 02115, USA.
Richard OrtizDepartment of Psychology, Northern Illinois Univ, DeKalb, IL, 60112, USA.
Joshua LeastonStanford Medical School, Palo Alto, CA, 94301, USA.
Praveen KulkarniCenter for Translational Neuroimaging, Northeastern University, Boston, MA, 02115, USA.
Rosemarie HightowerCenter for Translational Neuroimaging, Northeastern University, Boston, MA, 02115, USA.
Sophia PromCenter for Translational Neuroimaging, Northeastern University, Boston, MA, 02115, USA.
Nicholas O'HareDepartment of Bioengineering, Northeastern University, Boston, MA, 02115, USA.
Eno EbongDepartment of Bioengineering, Northeastern University, Boston, MA, 02115, USA.
Craig F FerrisCenter for Translational Neuroimaging, Northeastern University, Boston, MA, 02115, USA. c.ferris@northeastern.edu.ORCID http://orcid.org/0000-0001-9744-5214

Funding

Atheroprotective vs. Atherogenic Glycocalyx Mechanotransduction MechanismsK01HL125499 · NHLBI · NORTHEASTERN UNIVERSITY · PI EBONG, ENO ESSIEN · 2015 to 2019
$770k
NHLBI NIH HHS K01 HL125499
6 · The paper itself

Abstract

Mild repetitive head injury is a serious health problem with long-term negative consequences. Changes in brain neurobiology were assessed with MRI in a model of head injury designed to reflect the human experience. Rats were maintained on a reverse light-dark cycle and head impacted daily at 24 h intervals over three days while fully awake under red light illumination. There was no neuroradiological evidence of brain damage. Rats were imaged for changes in blood brain barrier permeability, edema and gray matter microarchitecture, and resting state functional connectivity. Data were registered to a 3D MRI rat atlas with 173 segmented brain areas providing site-specific information on each imaging modality. Changes in BBB permeability were minimal and localized to the hippocampus and cerebellum. There was evidence of cytotoxic edema in the basal ganglia, thalamus, and cerebellum. There was a global decrease in connectivity and an increase in gliosis in the thalamus, cerebellum, and hippocampus. This study shows a sequelae of neuropathology caused by mild repetitive head injury that is commonly observed in clinical practice using MRI in patients. As such, it may serve as a model for testing the efficacy of new therapeutics using any or all of the measures as biomarkers to assess drug efficacy.

Indexed as

BrainCraniocerebral TraumaMagnetic Resonance ImagingAnimalsBlood-Brain BarrierDisease Models, AnimalMaleMultimodal ImagingRatsRats, Sprague-DawleyWakefulnessAstrogliosisCerebral small vessel diseaseConcussionFerumoxytol

Identifiers

PMID40581885
PMCPMC12433400

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.