ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2025
Increased Aβ40 in plasma is associated with severity of exposure to airborne pollutants at the World Trade Center: a cross-sectional study of neurological biomarkers.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- World Trade Center neurotoxicant exposure severity is associated with cortical thinning and regional brain atrophy: a neuroimaging study of general responders at midlife.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Review
- White matter microstructural abnormalities in neurological poste-acute sequelae of coronavirus disease: Imaging signatures consistent with persistent neuroinflammation.Brain, behavior, & immunity - health · 2026Article
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Authors and funding
10 authors.
Funding
Abstract
World Trade Center (WTC) responders who were more severely exposed to the airborne pollution while working in rescue and recovery work would have heightened circulating levels of β-Amyloid (Aβ) levels in plasma. Plasma for 905 WTC responders was retrieved in 2019 and flash frozen and assayed using single molecule analysis to measure circulating levels of two subtypes of Aβ (Aβ40, Aβ42), alongside phosphorylated tau-181, glial fibrillary acidic protein (GFAP), and neurofilament-light. Plasma data were linked to demographics, blood volume, apolipoprotein-ε4 status, and medical outcomes as well as, in a subsample, with neuroimaging-based measures of cortical thickness. Amyloidogenesis was measured using the ratio of observed/expected levels of Aβ40 and labeled Normalized Aβ40. Spearman's rho was used to examine correlations; generalized linear modeling was used to examine multivariable-adjusted associations. The average age of WTC responders was 55.98 years, and 73.9% had completed at least some college. Observed Aβ40 levels were 24.61% higher than expected values, and lower in minimally exposed WTC responders as compared to severely exposed WTC responders (17.26 vs 44.48%, P = .005). Results remained statistically significant upon adjusting for covariates (adjusted blood volume ratio = 1.11 [1.02-1.22] P = .019). Normalized Aβ40 levels were associated with higher measures of phosphorylated tau-181, Aβ42, GFAP, and neurofilament-light in serology as well as, in a subsample (n = 70), with reduced cortical thickness (rho = -0.29, P = .020). Increased amyloidogenesis may be a neuropathological response in people who are severely or chronically exposed to airborne neurotoxic pollutants.
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