Evidence map›Paper›PMID 40581828›Full record

ArticleThe Journal of infectious diseases2025

Assessing the Potential of Sexual Transmission of Lassa Virus in a Natural Rodent Reservoir.

Jérémie Prévost, Nikesh Tailor, Geoff Soule, Kathy Frost, Kimberly Azaransky, Kevin Tierney, Heinz Feldmann, Stephanie Booth, Kyle Rosenke, David Safronetz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jérémie PrévostSpecial Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
Nikesh TailorSpecial Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
Geoff SouleSpecial Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
Kathy FrostOne Health Division, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.ORCID 0009-0005-1083-8899
Kimberly AzaranskySpecial Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
Kevin TierneySpecial Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
Heinz FeldmannLaboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Stephanie BoothOne Health Division, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.ORCID 0000-0001-8108-5955
Kyle RosenkeLaboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
David SafronetzSpecial Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.ORCID 0000-0002-9024-728X

Funding

National Institute of Allergy and Infectious DiseasesNIH HHSPublic Health Agency of Canada
6 · The paper itself

Abstract

Lassa virus (LASV) is maintained in and transmitted by Mastomys natalensis across West Africa. To date, few studies have addressed transmission of LASV between rodents. Here, we experimentally assessed the potential for sexual transmission of LASV in Mastomys. Intravaginal challenge led to systemic infection in females within 7 days of inoculation and persisted throughout the study. Percutaneous injection of males similarly resulted in a systemic infection, with LASV documented in reproductive organs and sperm for 21-42 days. Our data support the potential of sexual transmission of LASV in rodents, and intravaginal infection is potentially conducive to intrauterine transmission of LASV.

Indexed as

Lassa FeverMurinaeSexually Transmitted Diseases, ViralAnimalsDisease ReservoirsFemaleLassa virusMaleSpermatozoaVaginaarenavirusLassa virusMastomys natalensisreservoir hostsexual transmission

Identifiers

PMID40581828
PMCPMC12614994

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.