ArticleBiophysical journal2026
The effects of bicarbonate on the aberrant photon response in murine rod photoreceptors.
Article in Biophysical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Retinal rod photoreceptors generate reproducible quantal responses, enabling them to "count" single photons. Interestingly, in mammalian rods, one photoisomerization in several hundred elicits an aberrant response that is larger than normal and persists for a variable period lasting up to tens of seconds. Although rare, aberrant responses influence signaling because many rods converge onto downstream neurons and because "normal" and aberrant single-photon responses temporally summate in steady light. Bicarbonate increases the normal photon response and the maximal response of rods, but its effect on the aberrant responses is not known. To find out, we used a fully space-resolved, biophysical model of visual transduction in the murine rod and corroborated the results with ex vivo electroretinogram (ERG) recordings. In our simulations, the increased circulating current with bicarbonate raised [Ca
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