ArticleJournal of neuropathology and experimental neurology2025
Quantification of Alzheimer disease neuropathology using tissue microarrays.
Article in Journal of neuropathology and experimental neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Short T1 Fraction as a Marker of Myelin Content: Evidence from Postmortem MRI and Histology.bioRxiv : the preprint server for biology · 2026Article
- Quantification of the neuropathology of alcohol use disorder using tissue microarrays.Journal of neuropathology and experimental neurology · 2026Article
- Brain banking for research: can we achieve efficient banking?Frontiers in neurologyArticle
- An Australian brain bank and the future of alcohol and major neuropsychiatric disorders research.Frontiers in neurologyReview
- Antibody elution methods for multiplex immunofluorescence of Alzheimer's disease pathology in human post-mortem brain tissue.Frontiers in neurologyArticle
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Authors and funding
7 authors.
Funding
Abstract
Alzheimer's disease (AD) is characterized by the hallmark pathologies of β-amyloid plaques and neurofibrillary tangles (NFTs), which vary across brain regions and between affected individuals. As a rapid research method to quantify hallmark pathologies and their relationships with the surrounding cytoarchitecture across the brain, we trialed tissue microarrays (TMAs) in combination with multiplex immunofluorescence and semi-automated image analysis. We assayed the hallmark pathologies across grey and white matter sites of 11 different brain regions and quantified astrocytes, microglia, and neurons in four AD cases and four age- and gender-matched controls. The results demonstrated that 2 mm cores differentiated AD-affected individuals from healthy donors. Regional amyloid loads corroborated the established spread from the neocortex to allocortex, pontine, and occasionally cerebellar regions. Similarly, NFT counts matched the pattern predicted by Braak staging. Contrasting with the two hallmark pathologies, regional cell numbers were similar between cases and controls although cell counts were affected by variable staining quality. These results suggest that TMAs in combination with multiplex immunofluorescence and image analysis offer a powerful research tool for the rapid assessment of brain-wide AD neuropathological change in postmortem tissue. This quick assessment allows an informed selection of regions for more comprehensive investigations.
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