Evidence map›Paper›PMID 40581775›Full record

Trial reportJournal of the International Society of Sports Nutrition2025

Low-dose caffeine enhances cognitive processing but not physical performance in fatigued taekwondo athletes: a randomized crossover trial.

Alisa Nana, Papatsorn Ramyarangsi, Luksika Jamwai, Poomwut Hiranphan, Vorasith Siripornpanich, Amornpan Ajjimaporn

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of the International Society of Sports Nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Acute effects of 3 and 6 mg·KgJournal of the International Society of Sports Nutrition · 2026
    Trial
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alisa NanaMahidol University, College of Sports Science and Technology, Nakhonpathom, Thailand.ORCID 0000-0002-8592-8398
Papatsorn RamyarangsiMahidol University, College of Sports Science and Technology, Nakhonpathom, Thailand.ORCID 0000-0002-3925-7036
Luksika JamwaiMahidol University, College of Sports Science and Technology, Nakhonpathom, Thailand.ORCID 0009-0004-7346-3417
Poomwut HiranphanMahidol University, College of Sports Science and Technology, Nakhonpathom, Thailand.ORCID 0009-0006-1275-9059
Vorasith SiripornpanichMahidol University, Research Center for Neuroscience, Institute of Molecular Biosciences, Nakhonpathom, Thailand.ORCID 0000-0002-6614-4520
Amornpan AjjimapornMahidol University, College of Sports Science and Technology, Nakhonpathom, Thailand.ORCID 0000-0001-6009-3147

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCaffeine is commonly used to combat fatigue and enhance both cognitive and physical performance. However, its effects on neurophysiological responses and sport-specific performance following fatigue induction remain unclear, particularly in combat sports such as Taekwondo. This study investigated the effects of a 200 mg caffeine dose on physiological markers, electroencephalographic (EEG) brainwave activity, auditory P300 event-related potentials (ERPs), and Taekwondo-specific performance following combined mental and physical fatigue.

methodsThirteen male Taekwondo athletes participated in a randomized, double-blind, crossover study with caffeine (CAF) and placebo (PLA) conditions. Measurements were taken at baseline (pre-supplementation), 30 minutes post-supplementation (post-Sup), and after fatigue induction (post-I). Physiological parameters (heart rate, blood glucose, blood lactate, and ratings of perceived exertion), EEG brainwave activity during resting eyes-open conditions, auditory P300 ERPs, and Taekwondo-specific agility (TSAT) were assessed at all time points.

resultsCaffeine significantly reduced delta wave power at frontal and parieto-occipital sites at post-Sup (

conclusionA single 200 mg dose of caffeine reduced central fatigue and enhanced cognitive processing, as reflected by suppressed delta wave activity at post-Sup and increased P300 amplitude at post-I. However, caffeine did not influence physiological responses or Taekwondo-specific performance. These findings suggest that low-dose caffeine primarily benefits cognitive function rather than physical performance in combat sports. Future studies should explore dose-response relationships and individual variability in caffeine metabolism to optimize its application in competitive settings.

Indexed as

Athletic PerformanceCaffeineCentral Nervous System StimulantsCognitionFatigueMartial ArtsPerformance-Enhancing SubstancesAdultBlood GlucoseCross-Over StudiesDouble-Blind MethodElectroencephalographyEvent-Related Potentials, P300Heart RateHumansLactic AcidBlood GlucoseCaffeineCentral Nervous System StimulantsLactic AcidPerformance-Enhancing Substancesauditory P300 event-related potentialsbrain activityCentral fatiguecombat sportsperipheral fatigue

Identifiers

PMID40581775
PMCPMC12207766

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.