SynthesisAnnals of nuclear medicine2025
Diagnostic performance of FDG PET/CT radiomics in predicting microvascular invasion in hepatocellular carcinoma compared to conventional metabolic parameters: a systematic review and meta-analysis.
Synthesis in Annals of nuclear medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- An exploratory nomogram model withJournal of gastrointestinal oncology · 2026Article
- Decision-Making Biomarkers Guiding Therapeutic Strategies in Hepatocellular Carcinoma: From Prediction to Personalized Care.Cancers · 2025Review
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Authors and funding
3 authors.
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Abstract
purposeThe purpose of the current study was to evaluate the diagnostic accuracy of FDG PET/CT radiomics in predicting microvascular invasion (MVI) in hepatocellular carcinoma (HCC), and to compare it with conventional metabolic parameters of FDG PET/CT through a systematic review and meta-analysis.
methodsThe PubMed, EMBASE, and Cochrane databases were searched for studies evaluating the diagnostic performance of FDG PET/CT in predicting MVI in HCC patients. We calculated the pooled area under the curve (AUC) for predicting MVI using FDG PET/CT analyzed with radiomics methods and compared the results with those predicted through visual or semi-quantitative analysis. The study was conducted and registered in PROSPERO (International Prospective Register of Systematic Reviews) with the registration number CRD42023466842.
resultsThe pooled AUC for predicting MVI from three studies (274 patients) analyzed using radiomics methods was 0.79 (95% CI; 0.75-0.84), with various model algorithms and selected features. The pooled AUC for six studies (368 patients) using visual analysis was 0.76 (95% CI; 0.73-0.80), and the pooled AUC for nine studies (661 patients) using semi-quantitative analysis was 0.80 (95% CI; 0.76-0.83). The diagnostic performance of the three analysis methods did not show a statistically significant difference.
conclusionFDG PET/CT radiomics for predicting MVI in HCC showed diagnostic performance similar to that of conventional visual or semi-quantitative analysis methods. Further large-scale multicenter studies are necessary to substantiate the diagnostic accuracy of FDG PET/CT radiomics for predicting MVI in HCC patients.
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