SynthesisSleep & breathing = Schlaf & Atmung2025
Efficacy and safety of Chaihu plus Longgu Muli decoction combined with Estazolam in the treatment of insomnia: a meta-analysis.
Synthesis in Sleep & breathing = Schlaf & Atmung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Metal Ions in Longgu (Fossilized Bone) as a Natural Synergistic Network for Multi-Target Therapy in Psychiatric Disorders.Chemistry & biodiversity · 2026Review
- Shanghan Lun and Gam Saan songs for older Chinese Americans with insomnia.Sleep & breathing = Schlaf & Atmung · 2025Article
- Machine learning-assisted network pharmacology reveals that the Chaihu-Longgu-Muli decoction modulates the inflammatory microenvironment to treat perimenopausal syndrome.Frontiers in molecular biosciences · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundInsomnia is a major sleeping disorder that affects the quality of life and overall health in a tremendous way. Those pharmacological therapies of insomnia, which are typically applied, i.e., benzodiazepines, may result in side effects that are rather dangerous, i.e., dependency and the decline of the cognitive status. Chaihu plus Longgu Muli decoction is a traditional Chinese herbal formula (TCM) which has been used in the treatment of insomnia and can be used as a safer alternative or complementary approach in the treatment of this ailment. METHOS: PubMed, Embase, Cochrane library, CNKI, Wanfang, CQVIP and CBM databases have been searched in our meta-analysis since the establishment of the databases to July 2024. The studies containing the combination of Chaihu Longgu Muli decoction and Estazolam in treating insomnia were to be included in the proposed study without taking into consideration the published literatures, unpublished literatures, those which contain in-complete or inadequate information, animal experiments, literature synthesis and the systematic study. Data analysis was done on the STATA 15.1.
resultsThe meta-analysis revealed that the blend of Chaihu plus Longgu Muli decoction and Estazolam used to be extra potent than Estazolam treatment in enhancing the quality of sleep, as indicated by higher effective rates (RR = 1.29, 95% CI: 1.20-1.38, P = 0.000) and lower Pittsburgh Sleep Quality Index (PSQI) scores (WMD=-2.98, 95% CI: -4.06 to -1.90, P = 0.000). Also, lesser Traditional Chinese Medicine (TCM) syndrome scores followed the mixture therapy (WMD=-4.04, 95% CI: -4.38 to -3.70, P = 0.000) and reduced incidence of adverse events (RR = 0.35, 95% CI: 0.16-0.76, P = 0.000).
conclusionThe combination of Chaihu plus Longgu Muli decoction and Estazolam is more effective and safer than Estazolam alone in treating insomnia. This integrative approach could offer a promising alternative for patients seeking effective and safer treatment options for insomnia.
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