ArticlePediatric research2026
Lung function in adults born with very low birth weight from young to mid-adulthood.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Does neonatal sepsis affect the lung function of children and adults born prematurely?Pediatric research · 2026Article
- Article
- Bronchopulmonary dysplasia and extremely preterm birth: time for a broader perspective on long-term outcomes.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Mitochondrial quality control mechanisms as molecular targets for impaired lung development: from fetuses to neonates.Respiratory research · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundYoung adults born preterm with very low birth weight (VLBW; <1500 g), especially those who had neonatal bronchopulmonary dysplasia (BPD), have reduced lung function compared with their term-born peers. We hypothesized that these impairments worsen between young and mid-adulthood.
methodsWe studied two birth cohorts: HeSVA (Finland) and NTNU LBW Life (Norway) with harmonized protocols. Lung function was assessed by spirometry in 115 VLBW (20 with BPD) and 142 controls at mean 36 years. The results were compared with young adulthood (22 years) spirometry in 198 VLBW (32 with BPD) and 225 control participants.
resultsIn mid-adulthood, BPD-VLBW adults had lower z-scores in forced expiratory volume in 1 s (zFEV1; mean difference -1.49; 95%CI -1.94, -1.04) and in zFEV1/FVC (FVC: forced vital capacity; mean difference -0.84, 95%CI -1.23, -0.44) than controls. Corresponding differences for non-BPD-VLBW adults were -0.34 (95%CI -0.60, -0.08) and -0.30 (95%CI -0.53, -0.07). The differences in zFVC and zFEV1 between BPD-VLBW and control groups increased from young to mid-adulthood.
conclusionIn mid-adulthood, adults born preterm with VLBW had reduced airflow compared with term-born controls. These differences were more pronounced among those with a history of BPD, whose vital capacity also seems to decline faster. IMPACT: Impaired airflow and reduced vital capacity in VLBW adults do not improve with age. Among those with a history of BPD, vital capacity seems to reduce faster than among their term-born peers. Clinicians who see adults born preterm with VLBW should be vigilant for respiratory symptoms. We argue that a full medical history in all adults who present with respiratory symptoms should routinely include key birth characteristics such as preterm birth.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.