Evidence map›Paper›PMID 40581699›Full record

Trial reportPediatric research2026

Filtered-sunlight phototherapy for newborns with moderate-to-severe hyperbilirubinemia: a randomized trial.

Bolajoko O Olusanya, Olufemi M Omololu, Folashade B Osamebor, Anuoluwapo Olufosoye, Temitope Alo, Serah M Olaifa, Abieyuwa A Emokpae, Jacob O Olusanya, Cecilia A Mabogunje

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02612727 (Filtered Sunlight Phototherapy to Treat Significant Jaundice), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02612727 nacompletednot on this map

Filtered Sunlight Phototherapy to Treat Significant Jaundice: Safety and Efficacy in Neonates

TypeinterventionalSponsorUniversity of MinnesotaRan2012 to 2013Enrolled174ConditionsJaundice, NeonatalArmsFiltered-sunlight phototherapy, Intensive phototherapy
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bolajoko O OlusanyaCentre for Healthy Start Initiative, Ikoyi, Lagos, Nigeria. bolajoko.olusanya@uclmail.net.ORCID http://orcid.org/0000-0002-3826-0583
Olufemi M OmololuLagos Island Maternity Hospital, Lagos, Nigeria.
Folashade B OsameborCentre for Healthy Start Initiative, Ikoyi, Lagos, Nigeria.
Anuoluwapo OlufosoyeCentre for Healthy Start Initiative, Ikoyi, Lagos, Nigeria.
Temitope AloCentre for Healthy Start Initiative, Ikoyi, Lagos, Nigeria.
Serah M OlaifaMassey Street Children's Hospital, Lagos, Nigeria.
Abieyuwa A EmokpaeMassey Street Children's Hospital, Lagos, Nigeria.
Jacob O OlusanyaCentre for Healthy Start Initiative, Ikoyi, Lagos, Nigeria.
Cecilia A MabogunjeMassey Street Children's Hospital, Lagos, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFiltered-sunlight phototherapy (FSPT) is safe and non-inferior to conventional phototherapy for treating mild-to-moderate hyperbilirubinemia during birth hospitalization. We evaluated the performance of FSPT among newborns with moderate-to-severe hyperbilirubinemia.

methodsNewborns were randomized to FSPT or intensive electric phototherapy (IEPT). Primary outcomes were safety, defined as the absence of hyperthermia, hypothermia, dehydration, or sunburn; and efficacy, defined as the rate of increase in total serum or plasma bilirubin (TSB) < 3.4 µmol/L/h for newborns aged ≤72 h or a decrease in TSB for newborns aged >72 h who received ≥4 h of phototherapy. Secondary outcomes were night-time phototherapy, exchange transfusion (ET), and neonatal mortality rates.

resultsSome 104 newborns were assigned to FSPT (n = 52) or IEPT (n = 52). Mean irradiance was 27.7 ± 7.3μW/cm²/nm under FSPT and 36.1 ± 8.3μW/cm²/nm under IEPT. FSPT and IEPT were 93.4% and 93.3% efficacious in all treatment days, respectively. No newborn developed controlled hyperthermia or met the criteria for withdrawal for safety reasons under FSPT. Night-time phototherapy was more frequent under FSPT (52.5%) than IEPT (43.4%). Three neonates (FSPT = 2 and IEPT = 1) had ET. No baby died.

conclusionWhere practicable, FSPT is safe and non-inferior to IEPT for treating neonates with moderate-to-severe hyperbilirubinemia during birth hospitalization when there is no effective IEPT. CLINICAL TRIALS: GOV NUMBER: NCT02612727 (24/11/2015). IMPACT: Filtered-sunlight phototherapy (FSPT) is safe and efficacious for treating newborns with moderate-to-severe hyperbilirubinemia during birth hospitalization. Compared to intensive electric phototherapy, FSPT is not associated with higher rates of exchange transfusion or mortality. The incidence of hazardous hyperbilirubinemia with or without acute bilirubin encephalopathy is rare within 72 h of life in a population with high prevalence of G6PD deficiency and ABO incompatibility risk. In settings where intensive electric phototherapy that meets the recommended minimum irradiance threshold of 30 μW/cm²/nm cannot be assured, FSPT should be considered for at least 4 h for newborns with moderate-to-severe hyperbilirubinemia when practicable.

Indexed as

Hyperbilirubinemia, NeonatalPhototherapyBilirubinExchange Transfusion, Whole BloodFemaleHumansInfant MortalityInfant, NewbornMaleSeverity of Illness IndexTreatment OutcomeBilirubin

Identifiers

PMID40581699

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.