Evidence map›Paper›PMID 40581665›Full record

ArticleVirology journal2025

Genetic characterization of type 3 vaccine-derived poliovirus from a patient with hand, foot, and mouth disease in China.

Wei Zhang, Dongmei Yan, Hanri Zeng, Lei Zhou, Huanying Zheng, Shuangli Zhu, Yong Zhang, Baisheng Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wei Zhang *Guangdong Provincial Key Laboratory of Pathogen Detection for Emerging Infectious Disease Response, Provincial Center for Disease Control and Prevention, Guangdong Workstation for Emerging Infectious Disease Control and Prevention, Chinese Academy of Medical Sciences, No. 160, Qunxian Road, Panyu District, Guangzhou, China.
Dongmei Yan *National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, No. 155 Changbai Road, Changping District, Beijing, 102206, China.
Hanri ZengGuangdong Provincial Key Laboratory of Pathogen Detection for Emerging Infectious Disease Response, Provincial Center for Disease Control and Prevention, Guangdong Workstation for Emerging Infectious Disease Control and Prevention, Chinese Academy of Medical Sciences, No. 160, Qunxian Road, Panyu District, Guangzhou, China.
Lei ZhouNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, No. 155 Changbai Road, Changping District, Beijing, 102206, China.
Huanying ZhengGuangdong Provincial Key Laboratory of Pathogen Detection for Emerging Infectious Disease Response, Provincial Center for Disease Control and Prevention, Guangdong Workstation for Emerging Infectious Disease Control and Prevention, Chinese Academy of Medical Sciences, No. 160, Qunxian Road, Panyu District, Guangzhou, China.
Shuangli ZhuNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, No. 155 Changbai Road, Changping District, Beijing, 102206, China.
Yong Zhang *National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, No. 155 Changbai Road, Changping District, Beijing, 102206, China. yongzhang75@sina.com.
Baisheng Li *Guangdong Provincial Key Laboratory of Pathogen Detection for Emerging Infectious Disease Response, Provincial Center for Disease Control and Prevention, Guangdong Workstation for Emerging Infectious Disease Control and Prevention, Chinese Academy of Medical Sciences, No. 160, Qunxian Road, Panyu District, Guangzhou, China. libsn@126.com.

Funding

Guangdong Provincial Center for Disease Control and Prevention Supports Talent Projects 0720240122Guangdong Provincial Key Laboratory of Pathogen Detection for Emerging Infectious Disease 2023B1212010010
6 · The paper itself

Abstract

backgroundThe Oral Polio Vaccine (OPV) is genetically unstable and may mutate to form vaccinederived polioviruses (VDPVs). At present, the finding of VDPV mainly come from AFP surveillance and environmental sewage surveillance.

methodsIn 2023, a vaccine-derived poliovirus (VDPV) strain type 3 isolated from a patient with hand, foot, and mouth disease (HFMD) in Guangdong Province, China, was sequenced and analyzed.

resultThe strain had reversion mutations at the known attenuation site 5' non-coding region and recombined with Sabin1, Phylogenetic analysis of the VP1 coding region showed that the Guangdong type 3 VDPV evolved independently of other type 3 VDPVs found globally.

conclusionIt is meaningful to increase the sensitivity of surveillance of other enteroviral diseases for polioviruses.

Indexed as

Hand, Foot and Mouth DiseasePoliovirusPoliovirus Vaccine, OralChinaHumansMolecular Sequence DataPhylogenyRecombination, GeneticRNA, ViralSequence Analysis, DNAPoliovirus Vaccine, OralRNA, ViralHand, foot, and mouth diseasePoliovirusVaccine-derived poliovirus

Identifiers

PMID40581665
PMCPMC12205517

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.