Trial reportMolecular psychiatry2025
Comparative effects of 10-Hz rTMS and iTBS on cortico-striatal connectivity in major depressive disorder: a sham-controlled study.
Trial report in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Differential neural responses to rhythmic and patterned TMS protocols: Insights from EEG spectral analysis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Impact of Comorbid Generalized Anxiety Disorder on rTMS/iTBS Clinical Outcomes in Major Depression: A Multicenter Registry-Based Observational Study.Journal of personalized medicine · 2026Article
- iTBS Improves Behavioral Abnormalities and Synaptic Defects in Fmr1 KO Rats by Regulating the Autophagy Pathway.Molecular neurobiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormalities in the prefrontal cortex (PFC)-related network play an important role in the pathophysiology of major depressive disorder (MDD). Accumulating evidence indicated that fronto-striatal dysconnectivity is critical to MDD pathogenesis. Whether non-invasive brain stimulation, including 10-Hz repetitive transcranial magnetic stimulation (rTMS) and intermittent theta-burst stimulation (iTBS), may change cortico-striatal functional connectivity (FC) in MDD patients is unclear. Whether the change of cortico-striatal FC is associated with the antidepressant effects is also unknown. In total, 68 adult MDD subjects were randomly assigned to one of three groups: iTBS, 10-Hz rTMS, or sham group. Functional connectivity was analyzed using MRI and seed-based methods. Seeds included left and right dorsal caudate (DC), dorsal rostral putamen (DRP), and ventral rostral putamen (VRP). The results revealed that significant group-by-time interactions in FC were found in all the striatal seeds. Post-hoc analyses revealed significant increases in FC of the left DRP and VRP for both iTBS and rTMS treatments, particularly with the right frontal pole. Greater FC changes of the fronto-striatal networks correlated with the antidepressant effects. The effects of rTMS and iTBS on FCs of the intra-striatal network, default mode network, and other cortico-striatal networks were distinct. In conclusion, the first study demonstrated that iTBS and rTMS had common but unique effects on the cortico-striatal and intra-striatal networks. These results suggest that both treatments regulate brain reward systems and might be used to treat various striatum-related neuropsychiatric illnesses.
Indexed as
Identifiers
40581658What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.