Evidence map›Paper›PMID 40581654›Full record

Articlenpj aging2025

Mediterranean diet component oleic acid decreases systemic impact of periodontal Porphyromonas gingivalis-infection in age: addressing role of stress resistance and microbiome.

Annika Döding, Ludwig Wurschi, Cristina Zubiria-Barrera, Tilman E Klassert, Leonhard Bereuter, Zhigang Rao, Ann-Kathrin Bär, Anton Domuncu, Andreas Koeberle, Heidi Noels and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in npj aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Annika Döding *Section of Geriodontics, Department of Conservative Dentistry and Periodontology, Center of Dental Medicine, University Hospital Jena, Jena, Germany.
Ludwig Wurschi *Section of Geriodontics, Department of Conservative Dentistry and Periodontology, Center of Dental Medicine, University Hospital Jena, Jena, Germany.
Cristina Zubiria-BarreraRespiratory Infection Dynamics, Helmholtz Centre for Infection Research-HZI Braunschweig, Braunschweig, Germany.
Tilman E KlassertRespiratory Infection Dynamics, Helmholtz Centre for Infection Research-HZI Braunschweig, Braunschweig, Germany.
Leonhard BereuterMichael Popp Institute and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria.
Zhigang RaoMichael Popp Institute and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria.
Ann-Kathrin BärSection of Geriodontics, Department of Conservative Dentistry and Periodontology, Center of Dental Medicine, University Hospital Jena, Jena, Germany.
Anton DomuncuSection of Geriodontics, Department of Conservative Dentistry and Periodontology, Center of Dental Medicine, University Hospital Jena, Jena, Germany.
Andreas KoeberleMichael Popp Institute and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria.
Heidi NoelsInstitute for Molecular Cardiovascular Research (IMCAR), Uniklinik RWTH Aachen, RWTH Aachen University, Aachen, Germany.
Hortense SlevogtRespiratory Infection Dynamics, Helmholtz Centre for Infection Research-HZI Braunschweig, Braunschweig, Germany.
Bernd SiguschDepartment of Conservative Dentistry and Periodontology, Center of Dental Medicine, University Hospital Jena, Jena, Germany.
Ulrike Schulze-SpäteSection of Geriodontics, Department of Conservative Dentistry and Periodontology, Center of Dental Medicine, University Hospital Jena, Jena, Germany. ulrike.schulze-spaete@med.uni-jena.de.

Funding

Austrian Science Fund 10.55776/P36299Else Kröner-Fresenius-Stiftung Else Kröner Promotionskolleg JSAMGerman Federal Ministry of Education and Research (BMBF) 01EC1901B, Project 2Interdisciplinary Center of Clinical Research of the Medical Faculty Jena Doctoral ProgramInterdisciplinary Center of Clinical Research of the Medical Faculty Jena (IZKF) UKJ FF02
6 · The paper itself

Abstract

Periodontitis (PD) is an age-associated infectious periodontal disease driven by dysbiosis and hyperinflammatory host response, resulting in bone and tissue loss. Often linked to systemic inflammatory comorbidities, modulating host response emerged as promising clinical target. This study investigates whether nutritional intervention mitigates age-associated systemic impact of oral infection with PD key pathogen Porphyromonas gingivalis. Young (5 weeks) and aged (≥73 weeks) mice received palmitic acid-enriched Western-diet (PA-ED) or Mediterranean-diet enriched with oleic acid (OA-ED), both known for immunomodulatory properties. PA-ED exacerbated oral bone loss and systemic effects, particularly in aged mice, correlated with gut microbiota destabilization and impaired stress responses. Further, PA-ED enhanced osteoclast differentiation and primed bone marrow cells towards inflammation. Contrarily, OA-ED mitigated these effects. Osteoblasts showed baseline inflammation and reduced responsiveness in aged mice, thereby promoting a pro-inflammatory micro-environment. Findings suggest OA-ED as protective, especially for the elderly, by limiting local and systemic tissue damage associated with PD.

Identifiers

PMID40581654
PMCPMC12206234

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.