ArticleThe Plant cell2025
A root-specific NLR network mediates immune signaling of resistance genes against plant parasitic nematodes.
Article in The Plant cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Contrasting evolutionary patterns of helper and sensor NRC NLRs in lettuce reflect functional divergence following subfunctionalization.PLoS genetics · 2026Article
- An improved Solanum verrucosum genome provides insight into potato centromeres and epigenetic regulation.G3 (Bethesda, Md.) · 2026Article
- A chromosome-level genome assembly of Solanum brevicaule (PI 473011) Y1-5, a wild potato relative with robust resistance to potato cyst nematodes.The plant genome · 2026Article
- Haplotype-resolved t2t genome of paliurus hemsleyanus provides insights into rhamnaceae evolution and genome biology.Communications biology · 2025Article
- The autoactivity of tomato helper NLR immune proteins of the NRC clade is unaltered in Nicotiana benthamiana prf mutants.Plant physiology · 2025Article
- The resistance awakens: Diversity at the DNA, RNA, and protein levels informs engineering of plant immune receptors from Arabidopsis to crops.The Plant cell · 2025Review
- Helper NLR immune protein NRC3 evolved to evade inhibition by a cyst nematode virulence effector.PLoS genetics · 2025Article
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16 authors.
Funding
Abstract
Plant nucleotide-binding domain and leucine-rich repeat immune receptors (NLRs) confer disease resistance to many foliar and root parasites. However, the extent to which NLR-mediated immunity is differentially regulated between plant organs is poorly known. Here, we show that a large cluster of tomato (Solanum lycopersicum) genes, encoding the cyst and root-knot nematode disease resistance proteins Hero and MeR1 as well as the NLR helper NLR required for cell death 6 (NRC6), is nearly exclusively expressed in the roots. This root-specific gene cluster emerged in Solanum species about 21 million years ago through gene duplication of the ancient asterid NRC network. NLR sensors in this gene cluster function exclusively through NRC6 helpers to trigger hypersensitive cell death. These findings indicate that the NRC6 gene cluster has sub-functionalized from the larger NRC network to specialize in mediating resistance against root pathogens, including cyst and root-knot nematodes. We propose that some NLR gene clusters and networks may have evolved organ-specific gene expression as an adaptation to particular parasites and to reduce the risk of autoimmunity.
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