Evidence map›Paper›PMID 40581282›Full record

ArticleMicrovascular research2025

A theoretical model for oxygen transport to the cerebral cortex: effects of flow redistribution by penetrating arterioles.

Akshita Sharma, Timothy W Secomb

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microvascular research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Akshita SharmaProgram in Applied Mathematics, University of Arizona, Tucson, AZ, USA.
Timothy W SecombProgram in Applied Mathematics, University of Arizona, Tucson, AZ, USA; Department of Physiology, University of Arizona, Tucson, AZ, USA. Electronic address: secomb@arizona.edu.

Funding

Multiscale modeling of cerebral blood flow and oxygen transportU01HL133362 · NHLBI · UNIVERSITY OF ARIZONA · PI SECOMB, TIMOTHY W. · 2017 to 2021
$2.0M
NHLBI NIH HHS U01 HL133362
6 · The paper itself

Abstract

The goal of this study is to analyze the effects of changes of blood flow in penetrating arterioles (PAs) on the spatial distribution of tissue oxygen levels in the cerebral cortex. A theoretical model is used to simulate blood flow and oxygen transport in the cortical microcirculation. Networks containing up to 20,000 vessel segments, covering regions up to 1.1 mm

Indexed as

Cerebral CortexCerebrovascular CirculationMicrocirculationModels, CardiovascularOxygenArteriolesBlood Flow VelocityComputer SimulationHumansOxygen ConsumptionVasoconstrictionVasodilationOxygenBlood flow redistributionBrain blood flowBrain metabolismCerebral cortexPerfusionTissue oxygenation

Identifiers

PMID40581282
PMCPMC12279441

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.