Trial reportPhotodiagnosis and photodynamic therapy2025
Painless PDT using 10% aminolevulinate gel and red light: A pilot clinical trial of short-contact protocols to reduce discomfort during illumination.
Trial report in Photodiagnosis and photodynamic therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06027619 (Short Contact Protocols to Reduce Pain During Treatment of Actinic Keratoses With 10% ALA Gel Red-light Photodynamic Therapy), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Short Contact Protocols to Reduce Pain During Treatment of Actinic Keratoses With 10% ALA Gel Red-light Photodynamic Therapy (PDT)
Who cites it
2 citing papers in PubMed.
- The Evolving Landscape of Actinic Keratosis: Field Therapy, New Drugs, and Future Directions.American journal of clinical dermatology · 2026Review
- Emerging uses of 5-aminolevulinic-acid-induced protoporphyrin IX in medicine: a review of multifaceted, ubiquitous, molecular diagnostic, therapeutic, and theranostic opportunities.Journal of biomedical optics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundTraditional red light photodynamic therapy for actinic keratoses (AK) causes significant pain during illumination.
objectiveTo evaluate new short-incubation red light PDT regimens for their pain and efficacy characteristics.
methodsPatients (n = 30) with facial AK were treated with 10 % ALA gel (no occlusion) and red light (635 nm), after randomization as follows [incubation time, illumination time (fluence)]: Group A [10 min, 20 min (74 J/cm
resultsAt both treatment visits, Group A and B patients experienced negligible pain that was statistically less than that of Group C patients. AK clearance after two PDT treatments was robust and similar amongst the three treatment groups (76 % for Group A, 74 % for Group B, and 82 % for Group C). Using a non-inferiority margin of 15 %, lesion reduction in Group A was statistically non-inferior to Group C after one PDT treatment. LIMITATIONS: Efficacy rates of the new short incubation protocols (done without occlusion) were not compared directly with the long (3-hour) FDA-approved protocol that is done with occlusion.
conclusionShort-contact red light PDT regimens are essentially painless and appear to provide very good AK lesion clearance. CLINICAL
trial registrationNCT06027619 (date of trial registration: 31 August 2023).
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Registered trials
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