ArticleThe Journal of pediatrics2025
Count of Neonatal Morbidities Predicts Outcomes at Age 10 and 15 Years in Infants Born Extremely Preterm.
Article in The Journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Early predictors of cognitive trajectories from birth to adolescence in children born extremely preterm.Developmental medicine and child neurology · 2026Article
- Preterm Children in Iceland: Neonatal Morbidities and Motor Development in the First Two Years, and Later Disability Diagnosis.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Beyond Maximum Haemorrhage Grade: Serial Cranial Ultrasound Phenotyping Refines Developmental Risk Stratification After Intraventricular Haemorrhage in Very Preterm Infants.Journal of clinical medicine · 2026Article
- From Gram-Negative Neonatal Sepsis to Neurodevelopmental Impairment: A Retrospective Cohort Study in Preterm Infants.Children (Basel, Switzerland) · 2026Article
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Authors and funding
14 authors.
Funding
Abstract
objectiveTo assess whether a simple count of 5 common neonatal morbidities, including bronchopulmonary dysplasia (BPD), ultrasound-identified severe brain injury (SBI), severe retinopathy of prematurity (ROP), surgical necrotizing enterocolitis (NEC), and sepsis predict long-term neurocognitive impairment, general medical health, behavioral health, or quality of life (QOL) at age 10 and 15 years in children born extremely preterm. STUDY
designParticipants from the multicenter, prospective, longitudinal study extremely low gestational age newborns (ELGANs) were followed at ages 10 and 15 years and were categorized into groups with 0, 1, 2, or ≥3 neonatal morbidities (BPD, SBI, ROP, NEC, or sepsis). Long-term neurocognitive outcomes were assessed using latent profiles generated from standardized tests of intelligence and executive function. General medical health, behavioral health, and QOL were assessed using standardized assessments.
resultsOf 1198 participants who survived to age 10 889 (74.2%) and 694 (57.9%) were evaluated at age 10 and 15 years, respectively. The number of neonatal morbidities was linearly related to the probability of moderate-to-severe neurocognitive impairment at age 10 and 15 years, and the probability of motor impairment, legal blindness, severe hearing loss, number of health disorders, ≥2 health disorders, and poor QOL at age 10 years.
conclusionsAmong newborns born extremely preterm who survive long-term, a simple count of neonatal morbidities (including BPD, SBI, ROP, NEC, or sepsis) is linearly related to neurocognitive impairment, poor general health, and QOL.
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