ArticleDevelopmental cell2025
A dual enhancer-attenuator element ensures transient Cdx2 expression during mouse posterior body formation.
Article in Developmental cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Mechanisms underlying disease-causing variants in promoters and enhancers.Nature genetics · 2026Review
- Characterization of a cis-regulatory element upstream of matrix metalloproteinase-9.Scientific reports · 2025Article
- Posterior enhancer (p-Enh) maintains early neuromesodermal progenitors bi-potency during gastrulation.Cell regeneration (London, England) · 2025Article
- The exit from naive pluripotency: a platform for the study of enhancer mechanistics.Biochemical Society transactions · 2025Review
- Sp Transcription Factors Establish the Signaling Environment in the Neuromesodermal Progenitor Niche During Axial Elongation.bioRxiv : the preprint server for biology · 2025Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
During development, cells express precise gene expression programs to assemble the trunk of the body plan. Appropriate control over the duration of the transcription factor Cdx2 is critical to achieve this outcome, yet how cells control the onset, maintenance, or termination of Cdx2 has remained unclear. Here, we delineate the cis-regulatory logic orchestrating dynamic Cdx2 expression in mouse caudal epiblast progenitors and their derivatives. Combining CRISPR-mediated deletion of regulatory elements with in vitro models and in vivo validation, we demonstrate that distinct enhancers and a repressive element embedded at the Cdx2 locus act sequentially to drive transient Cdx2 expression. We pinpoint an "attenuator": a minimal region relying on a nuclear receptor to extinguish Cdx2. Changing this single motif converts the attenuator to an enhancer with the opposite regulatory behavior. Our findings establish a dual cis-regulatory logic ensuring precise spatiotemporal control over gene expression for vertebrate body patterning.
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Registered trials
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