Evidence map›Paper›PMID 40580813›Full record

ReviewCurrent opinion in structural biology2025

Fuzziness in enzymatic catalysis.

Sachin S Katti, Tvesha Parikh, Rachel J Godek, Rebecca Page, Wolfgang Peti

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in structural biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sachin S KattiDepartment of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT 06030, USA.
Tvesha ParikhDepartment of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA.
Rachel J GodekDepartment of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA.
Rebecca PageDepartment of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA. Electronic address: rpage@uchc.edu.
Wolfgang PetiDepartment of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT 06030, USA. Electronic address: peti@uchc.edu.

Funding

Serine/Threonine Phosphatases in Neurological DiseasesR01NS124666 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Wolfgang Peti · 2023 to 2026
$2.0M
Protein Phosphatase 1 Holoenzyme FormationR01GM144483 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI PETI, WOLFGANG · 2022 to 2025
$1.7M
The regulation of phosphoprotein phosphatases in the nucleusR01GM144379 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Rebecca Page · 2023 to 2026
$1.5M
NIGMS NIH HHS R01 GM144379NIGMS NIH HHS R01 GM144483NINDS NIH HHS R01 NS124666
6 · The paper itself

Abstract

Intrinsically disordered proteins/regions (IDPs/IDRs) frequently engage in dynamic charge:charge interactions, commonly referred to as 'fuzzy' interactions. These fuzzy interactions play critical roles in enzymatic regulation and substrate recruitment, especially for protein kinases and protein phosphatases. Here, we review recent advances that demonstrate how inter- and intramolecular fuzzy interactions among kinases and phosphatases and their cognate regulators and substrates allow for enzyme assembly, activation and substrate recruitment. We also highlight a unique mechanism of protein inhibition, where a protein phosphatase is inhibited by dynamic fuzzy interactions with its active site metals.

Indexed as

BiocatalysisIntrinsically Disordered ProteinsProtein KinasesHumansProtein BindingSubstrate SpecificityIntrinsically Disordered ProteinsProtein Kinases

Identifiers

PMID40580813
PMCPMC12225613

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.