ReviewCurrent opinion in structural biology2025
Applications of high-throughput reporter assays to gene regulation studies.
Review in Current opinion in structural biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Atlas of HIV cis-regulatory elements reveals extensive transcriptional variation across clades, isolates, and within individuals.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Determining the rules of transcriptional regulation, associated with a complex transcription factor grammar, is fundamental to understand the control of most biological processes, disease mechanisms, and evolution. High-throughput reporter assays, such as MPRAs and STARR-seq, have enabled systematic functional annotations of genomes and have provided large substrates for training machine learning models to determine these rules, predict the activity of native and synthetic elements, and design elements for different applications. This review provides an overview of high-throughput reporter assays and their applications for the study of enhancers, promoters, silencers and insulators. We discuss how these assays help identify causal disease-associated non-coding variants and design synthetic elements with desired features for functional studies or therapeutic purposes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.