Evidence map›Paper›PMID 40580666›Full record

SynthesisInternational dental journal2025

Effects of Xylitol-laced Sweets on the Accumulation of Dental Plaque : A Systematic Review and Meta-Analysis.

Mohammad Mostafazadehbakhtiyary, Sara Majidinia, MohammadHassan Sohouli, Hossein Chalakinia, Atefeh Sadat Langari, Sara Ziaaddini, Reza Shakiba, Shayan Yousefi

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International dental journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohammad MostafazadehbakhtiyaryPost-graduate Student, Department of Esthetic and Restorative Dentistry, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
Sara MajidiniaDental Material Research Center, School of Dentistry, Mashhad Univercity of Medical Sciences, Mashhad, Iran. Electronic address: Majidinias@mums.ac.ir.
MohammadHassan SohouliPediatric Gastroenterology and Hepatology Research Center, Pediatrics Centre of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: mohammadhassansohouli@gmail.com.
Hossein ChalakiniaDepartment of Cosmetic and Restorative Dentistry, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
Atefeh Sadat LangariAssistant Professor of Restorative Dentistry, Department of Operative Dentistry, North Khorasan University of Medical Sciences, Bojnourd, Iran.
Sara ZiaaddiniPost-graduate Student, Department of Esthetic and Restorative Dentistry, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
Reza ShakibaStudent research committee, Mashhad University of Medical Sciences, Mashhad, Iran.
Shayan YousefiSchool of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis meta-analysis was carried out in order to assess the effects of xylitol-laced sweets on the accumulation of dental plaque biofilm.

methodsUsing predetermined keywords, a systematic search was conducted using the original databases published until July 2024 on randomized controlled trials that evaluated the effect of xylitol-laced sweets on the accumulation of dental plaque. The random-effects model was used to obtain the 95% confidence intervals and the pooled weighted mean difference.

resultsA quantitative meta-analysis of 13 treatment arms of the included studies showed that xylitol-laced sweetssignificantly decreased the plaque index (PI) (WMD: -0.41, 95% CI: -0.62, -0.20, P < .001) and the quantity of plaque accumulation (WMD: -7.46 mg, 95% CI: -13.38, -1.53, P = .014) compared with thecontrol groups. The subgroup analysis showed that xylitol causes a greater decrease in plaque accumulation (PI and amount of plaque) in the dose of interventions ≤20 g compared to >20 g and also during the intervention <4 weeks compared to ≥4 weeks . In addition, the subgroup analysis shows a greater effect on PI reduction in those ≤ 18 years of age.

conclusionsOur findings show the potentially beneficial and significant effects of xylitol-laced sweets either in gummy or candy forms, on reducing plaque accumulation.

Indexed as

Dental PlaqueSweetening AgentsXylitolBiofilmsDental Plaque IndexHumansRandomized Controlled Trials as TopicSweetening AgentsXylitolChewing gumDental plaqueMaltitolMeta-analysisSorbitolXylitol

Identifiers

PMID40580666
PMCPMC12269386

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.