Evidence map›Paper›PMID 40580395›Full record

ArticleDocumenta ophthalmologica. Advances in ophthalmology2025

Detecting congenital chiasmal misrouting using multichannel VEPs: protocol for a scoping review.

Giulia Steuernagel Del Valle, Haipha Ali, John R Grigg, Ruth Hamilton, Michael B Hoffmann, Bruce Hudson, Wanda L Pfeifer, Dorothy A Thompson, Anupreet Tumber, Ajoy Vincent and 1 more

Abstract read
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In one paragraph

Article in Documenta ophthalmologica. Advances in ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Giulia Steuernagel Del ValleHospital de Olhos Do Paraná, Alameda Pres. Taunay, 483, Curitiba, 80420-180, Brazil. giuliadelvalle@yahoo.com.br.ORCID 0000-0001-6852-7683
Haipha AliFaculty of Medicine of Medicine and Health, Save Sight Institute, The University of Sydney, 8 Macquarie St, Sydney, NSW, 2001, Australia.
John R GriggFaculty of Medicine of Medicine and Health, Save Sight Institute, The University of Sydney, 8 Macquarie St, Sydney, NSW, 2001, Australia.
Ruth HamiltonDepartment of Clinical Physics and Bioengineering, Royal Hospital for Children, NHS Greater Glasgow and Clyde, Glasgow, UK.ORCID 0000-0002-0855-9533
Michael B HoffmannOphthalmic Department, Center of Behavioral Brain Sciences, Otto-Von-Guericke University Magdeburg, Magdeburg, Germany.ORCID 0000-0002-6452-9638
Bruce HudsonGlasgow Centre for Ophthalmic Research, Gartnavel General Hospital, NHS Greater Glasgow and Clyde, Glasgow, UK.
Wanda L PfeiferDepartment of Ophthalmology and Visual Sciences, University of Iowa Hospital and Clinics, Iowa City, USA.
Dorothy A ThompsonGreat Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.ORCID 0000-0001-5491-3911
Anupreet TumberDepartment of Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, ON, Canada.ORCID 0009-0002-8311-8508
Ajoy VincentDepartment of Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, ON, Canada.ORCID 0000-0001-6446-3846
Gerard C de WitBartiméus Diagnostic Center for Complex Visual Disorders, Zeist, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe present the protocol of a prospective scoping review which aims to understand how multi-channel visual evoked potentials (mcVEPs) are used to investigate congenital chiasmal misrouting and what outcomes are measured, interpreted and reported.

introductionmcVEPs are used for the objective evaluation of chiasmal misrouting, which is characterized by a crossed asymmetry in the distribution of cortical responses over each hemisphere during monocular stimulation, and is often observed in patients with albinism. The application and analysis of mcVEPs varies across centers, creating a need to explore the range of practice regarding their conduct and reporting and to identify potential areas for adaptation or optimization or guidelines for specific populations. INCLUSION CRITERIA: Peer reviewed and grey literature on the use of mcVEP to detect chiasmal misrouting in humans with non-acquired pathologies will be considered. All literature providing details of mcVEP methodology for replication and specification of chiasmal misrouting will be included for review.

methodsSearches will be conducted using MEDLINE, Embase, Cochrane and Web of Science with the expertise of a librarian. The search will be conducted with no limitation on time period, but will be restricted to the Latin alphabet. Titles and abstracts will be screened by two investigators with conflicts resolved by a third investigator. Included articles will proceed with data extraction on study details including methodology, design, and outcomes. The results will be synthesized and mapped for logical understanding.

Indexed as

Evoked Potentials, VisualOptic ChiasmHumansProspective StudiesScoping Reviews as TopicMultichannel visual evoked potentialsReviewScoping reviewVisual evoked potentials

Identifiers

PMID40580395

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.