Evidence map›Paper›PMID 40580312›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

Quality by design approach for nifedipine-adsorbed fluorite-loaded calcium-low methoxy pectin beads to impart chronotherapy: in vitro and in vivo assessment.

Rajesh S Jagtap, Shrinivas K Mohite, Sneha R Jagtap, Sameer J Nadaf, Sachin S Mali, Poournima S Sankpal, Sudarshan Singh

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Rajesh S JagtapDepartment of Pharmaceutics, Vijayrao Naik College of Pharmacy, Shirval-Kankavli Sindhudurg, Maharashtra, 416620, India. rajeshjagtap0807@gmail.com.
Shrinivas K MohiteDepartment of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy Kasegaon, Sangli, Maharashtra, India.
Sneha R JagtapLate Adv. Dadasaheb Chavan Memorial Institute of Pharmacy, Malwadi (Masur), Maharashtra, India.
Sameer J NadafDepartment of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Palus, Sangli, Maharashtra, 416310, India.
Sachin S MaliDepartment of Pharmaceutics (PG), Bharati Vidyapeeth College of Pharmacy, Kolhapur, 416 013, India.
Poournima S SankpalDepartment of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Palus, Sangli, Maharashtra, 416310, India.
Sudarshan SinghOffice of Research Administration, Chiang Mai University, Chiang Mai, 50200, Thailand. sudarshan.s@cmu.ac.th.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Majority of conventional oral delivery fails to maintain therapeutic concentration of drugs at site of action due to fast gastric-emptying time. Therefore, to overcome these inherent limitations and to improve pharmacokinetic parameters, a porous calcium silicate, fluorite (Florite RE®: FLR) and low methoxy (LM) pectin-based floating-pulsatile drug delivery system was developed for engineered specific drug release of nifedipine (NFD). FLR was investigated as multifaceted acting agent to act as solublizer and to impart pulsatile release. FLR-based NFD-loaded floating-pulsatile pectin beads were prepared using ionotropic gelation technique and optimized via 3

Indexed as

Calcium Channel BlockersCalcium CompoundsNifedipinePectinsSilicatesAdsorptionAnimalsBiological AvailabilityDelayed-Action PreparationsDrug CarriersDrug ChronotherapyDrug Delivery SystemsDrug LiberationMaleRatsSolubilityCalcium Channel BlockersCalcium Compoundscalcium silicateDelayed-Action PreparationsDrug CarriersNifedipinePectinsSilicatesCalcium silicateDesign of experimentLow methoxy pectinPharmacokineticPulsatile beads

Identifiers

PMID40580312

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.