ReviewHistochemistry and cell biology2025
A comprehensive review of histone modifications during mammalian oogenesis and early embryo development.
Review in Histochemistry and cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Molecular mechanisms of folliculogenesis and oogenesis.Systems biology in reproductive medicine · 2026Review
- Maternal age as a driver of genome instability: mechanisms linking aneuploidy, mutagenesis and mitochondrial dysfunction.Archives of toxicology · 2026Review
- Epigenetic blind spots - the role of DNA methylation dynamics in stem cell-based models of embryogenesis.FEBS letters · 2026Article
- Review
- Review
- Histone lactylation maintains bovine early embryo development via regulating embryonic genome activation.Journal of animal science and biotechnology · 2026Article
- Deciphering epigenetic crosstalk in multiple myeloma pathogenesis and treatment.Clinical epigenetics · 2026Review
- August in focus in HCB.Histochemistry and cell biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The success of both oogenesis and early embryo development relies heavily on dynamic epigenetic regulation in which gene activity changes without affecting the underlying DNA sequence. Epigenetics works through two main mechanisms: DNA methylation and histone modifications. DNA methylation typically leads to gene silencing, while histone modifications can either activate or repress genes depending on the specific modification, histone type, and targeted amino acid residue. Histone modifications affect important DNA regulatory processes in which the histone core area as well as the N-terminal tails that extend from the core region are vulnerable to a variety of posttranslational modifications (PTMs), including methylation, citrullination (deimination), acetylation, phosphorylation, ubiquitination, SUMOylation, ribosylation, and lactylation. This review article focuses on what is known about changes in the histone modifications and how these modifications and their responsible enzymes operate throughout mammalian oocyte maturation and early embryo development, highlighting their crucial roles in these processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.