Evidence map›Paper›PMID 40580211›Full record

ArticleEuropean journal of applied physiology2025

Mechanisms of exercise-induced reduction in peripheral arterial stiffness.

Natalia S Lima, Ronald E Jackson, Brooks A Hibner, Sara R Sherman, Bo Fernhall, Tracy Baynard, Craig Crandall, Shane A Phillips, Rrita Zejnullahi, Philip S Clifford

Abstract read
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In one paragraph

Article in European journal of applied physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Natalia S LimaIntegrative Physiology Laboratory, College of Applied Health Sciences, University of Illinois at Chicago, 1919 W Taylor St MC528, Chicago, IL, 60612, USA.ORCID http://orcid.org/0000-0001-9430-1557
Ronald E JacksonIntegrative Physiology Laboratory, College of Applied Health Sciences, University of Illinois at Chicago, 1919 W Taylor St MC528, Chicago, IL, 60612, USA.
Brooks A HibnerIntegrative Physiology Laboratory, College of Applied Health Sciences, University of Illinois at Chicago, 1919 W Taylor St MC528, Chicago, IL, 60612, USA.
Sara R ShermanIntegrative Physiology Laboratory, College of Applied Health Sciences, University of Illinois at Chicago, 1919 W Taylor St MC528, Chicago, IL, 60612, USA.
Bo FernhallIntegrative Physiology Laboratory, College of Applied Health Sciences, University of Illinois at Chicago, 1919 W Taylor St MC528, Chicago, IL, 60612, USA.
Tracy BaynardIntegrative Physiology Laboratory, College of Applied Health Sciences, University of Illinois at Chicago, 1919 W Taylor St MC528, Chicago, IL, 60612, USA.
Craig CrandallDepartment of Internal Medicine, University of Texas Southwestern, Dallas, TX, USA.
Shane A PhillipsIntegrative Physiology Laboratory, College of Applied Health Sciences, University of Illinois at Chicago, 1919 W Taylor St MC528, Chicago, IL, 60612, USA.
Rrita ZejnullahiIntegrative Physiology Laboratory, College of Applied Health Sciences, University of Illinois at Chicago, 1919 W Taylor St MC528, Chicago, IL, 60612, USA.
Philip S CliffordIntegrative Physiology Laboratory, College of Applied Health Sciences, University of Illinois at Chicago, 1919 W Taylor St MC528, Chicago, IL, 60612, USA. psc@uic.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPeripheral arterial stiffness measured with pulse wave velocity (PWV) is reduced 5-min after an acute bout of dynamic exercise. The mechanism for the reduction in peripheral arterial stiffness is unknown. We hypothesized that increased blood flow and compression of the vasculature are potential mechanisms involved in post-exercise reduction in peripheral arterial stiffness.

methodsBrachial-radial PWV was measured with tonometers on the exercising arm of 20 healthy young volunteers (10 females, 30 ± 5 yrs, mean ± SD) before and after 5 min of rhythmic handgrip exercise at 30% of maximal voluntary contraction (MVC), 50% MVC, and a 5 min set of passive forearm compressions. Brachial blood flow was monitored with Doppler ultrasound during exercise/compression.

resultsBrachial-radial PWV was lower than baseline at 5 min post (p < 0.001) for 30% MVC, 50% MVC, and compression, with responses similar among all conditions (p > 0.05). PWV remained lower than baseline at 15 min and 30 min only for 50% MVC. Blood flow and changes in brachial diameter during exercise/compression were not factors in the PWV reduction (p > 0.05).

conclusionThese findings suggest that compression of the forearm vasculature contributes to the initial reduction in peripheral PWV after handgrip exercise, but the reductions in peripheral PWV are not associated with changes in blood flow.

Indexed as

Brachial ArteryExerciseVascular StiffnessAdultBlood Flow VelocityFemaleForearmHand StrengthHumansMalePulse Wave AnalysisRegional Blood FlowBlood flowCompressionHandgripPulse wave velocity

Identifiers

PMID40580211
PMCPMC12678561

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.