Evidence map›Paper›PMID 40580190›Full record

ReviewMedical gas research2026

Gas mixture in noninvasive ventilation.

Mostafa Elshazly, Garuti Giancario, Benan Bayrakci, Jose Luis Sandoval, Hebatallah Hesham Ahmed, Antonio M Esquinas

Erratum issuedAbstract readReview
In one paragraph

Review in Medical gas research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Mostafa ElshazlyFaculty of Medicine, Cairo University, Giza, Egypt.
Garuti GiancarioPneumologo Unit, Santa Maria Bianca Hospital, Modena, Italy.
Benan BayrakciDepartment of Pediatric Intensive Care Medicine, Life Support Center, Hacettepe University, Ankara, Turkey.
Jose Luis SandovalInstituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico.
Hebatallah Hesham AhmedFaculty of Medicine, Cairo University, Giza, Egypt.ORCID 0009-0003-7233-3429
Antonio M EsquinasIntensive Care Unit, Hospital Meseguer, NIV-ICM, Instituto Murciano de Investigación Biosanitaria, Murcia, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Noninvasive ventilation (NIV) and high-flow nasal cannula are increasingly used to treat acute respiratory failure. Because many of these patients could also benefit from inhaled medications, combining aerosol therapy with NIV or high-flow nasal cannula is a promising approach. Effective drug delivery to the lungs is crucial for successful aerosol therapy during NIV. Prior research has identified several factors that affect aerosol delivery efficiency in NIV patients. Medical gases have a long history of use in managing various respiratory conditions. Among them, oxygen is frequently used for patients with hypoxia (e.g., hypoxemic respiratory failure and in newborns). In addition to deoxygenation, helium oxygen mixture and nitric oxide can also be administered through devices such as masks combined with NIV. This narrative review aims to provide a comprehensive overview on the application of gas mixtures (such as helium oxygen mixtures and nitric oxide) in NIV, focusing on their efficacy, safety, and optimization strategies in different clinical settings.

Indexed as

HeliumNoninvasive VentilationHumansNitric OxideOxygenHeliumNitric OxideOxygenaerosol drug deliverydrug delivery systemsgas mixtureshelioxhelium-oxygen mixtureinhalation therapyinhaled nitric oxidemetered-dose inhalernebulizernoninvasive ventilation

Identifiers

PMID40580190
PMCPMC12318578

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.