ArticleThe Journal of organic chemistry2025
Functionalization of Electron-Rich Secondary Benzyl Alcohols in HFIP: From Thioethers to Trisubstituted Methanes.
Article in The Journal of organic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Iron-Catalyzed Friedel-Crafts Reactions of Unactivated 3-Aryl-Oxetanols Exploiting HFIP Stabilization of Carbocations.The Journal of organic chemistry · 2026Article
- Unlocking Lewis acid-free metalation of O-nucleophiles in HFIP.Communications chemistry · 2026Article
- Synthesis of Unsymmetrical Dialkyl Ethers via Direct Etherification Cocatalyzed Using FeClACS omega · 2026Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
To date, C-S bond formation via dehydration of electron-rich secondary benzylic alcohols has been limited to catalytic approaches. In this work, we developed an efficient method for synthesizing various thioethers by employing hexafluoroisopropanol (HFIP) as a solvent. This approach also enables the functionalization of secondary benzyl alcohols with other important organic molecules, such as allylsilanes, activated arenes, and indoles, leading to various trisubstituted methanes, including 14 novel products in total.
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