ArticleActa paediatrica (Oslo, Norway : 1992)2025
The Aetiology of Elevated Total Serum Immunoglobulin E in Children.
Article in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Reply to the Letter: "Non-Syndromic elevated IgE": In reply to: Özdemir Ö. Non-syndromic elevated IgE. World Allergy Organization Journal 2026; 19:101420. Concerning: Castagnoli R, Pecoraro L, Mastrorilli C, et al. Non-syndromic hyper-IgE in children: a practical approach. World Allergy Organization Journal 2026; 19(3):101346.The World Allergy Organization journal · 2026Article
- Parasitic Infections as Reversible Hyper-IgE Phenocopies in Children with Markedly Elevated IgE: A Retrospective Cohort Study.Children (Basel, Switzerland) · 2026Article
- Serine/Threonine Kinase 4 Deficiency Caused by a Potential Novel c.248del, p.Pro83Leufs∗3 Mutation: A Case Report.Case reports in immunology · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
aimThe paucity of real-world data on the aetiology of elevated total serum immunoglobulin E (TS-IgE) in children afflicts families and health care systems with diagnostic uncertainty. We explored a cohort of children with TS-IgE levels over 1000 kU/L, focusing on the prevalence of atopic and non-atopic conditions, the aetiology of extremely elevated TS-IgE and the relevance of TS-IgE levels for the diagnosis of non-atopic diseases.
methodsData from paediatric patients managed at HUS Group hospitals in Finland between 1998 and 2024 were queried for TS-IgE levels and International Classification of Diseases (ICD)-10 diagnostic codes. A chart review was performed for patients with non-atopic conditions.
resultsOur cohort included 2431 children with TS-IgE levels over 1000 kU/L; for 2061 of them, ICD-10 codes were available. Non-atopic conditions rarely caused TS-IgE elevation (45/2061 patients, 2%), even in children with extremely high (> 15 000 kU/L, N = 76) TS-IgE levels. Graft-versus-host disease and inborn errors of immunity were the most common non-atopic aetiologies of TS-IgE elevation. All children with non-atopic conditions manifested distinct clinical symptoms, and TS-IgE level was irrelevant for reaching the diagnosis.
conclusionNon-atopic conditions were uncommon and clinically obvious in children with elevated TS-IgE; therefore, we question the diagnostic relevance of TS-IgE measurement.
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