ArticleJournal of diabetes investigation2025
Uric acid to high-density lipoprotein cholesterol ratio is associated with the prevalence of diabetic kidney disease in euthyroid patients with type 1 diabetes mellitus in China: A multicenter cross-sectional study.
Article in Journal of diabetes investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Cross-sectional association of the uric acid-to-HDL cholesterol ratio with diabetic kidney disease in patients with type 2 diabetes.Frontiers in nutrition · 2026Article
- Sex differences in the association between the uric acid to high density lipoprotein cholesterol ratio and mild cognitive impairment in patients with type 2 diabetes mellitus.Frontiers in nutrition · 2025Article
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5 authors.
Funding
Abstract
introductionGlobally, the inadequate diagnosis and treatment of diabetic kidney disease remains a significant challenge, impeding effective management. The uric acid to high-density lipoprotein cholesterol ratio (UHR) has been associated with type 2 diabetes; however, its role in euthyroid patients with type 1 diabetic kidney disease (T1DKD) remains unclear. The aim of this study was to assess the association between UHR and T1DKD in patients with euthyroidism.
methodsThis cross-sectional study included 335 euthyroid patients with type 1 diabetes mellitus (T1DM) from 1,485 eligible participants. Sociodemographic and blood test data were collected from inpatients of the endocrinology departments of 18 hospitals in Gansu Province.
resultsAmong the 335 euthyroid patients with T1DM (mean age 35.5 years, 57.6% males), 49.6% had T1DKD. In the fully adjusted model, T1DKD was positively associated with UHR (odds ratio [OR] = 2.29; 95% confidence interval [CI]: 1.36-3.87; P = 0.002). A positive relationship between T1DKD and UHR was also observed (nonlinear, P = 0.575). Subgroup analysis showed that this independent association remained consistent regardless of sex, body mass index, nationality, and marital status. The predictive value of UHR was ~22% higher in adults than in individuals aged <18 years.
conclusionsUHR is positively related to DKD in patients with euthyroid T1DM. Assessing the UHR might be a valuable part of follow-up visits for patients with T1DM.
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