ArticleAnnals of medicine2025
Association between triglyceride-glucose index and liver enzymes in adults with metabolic syndrome: a retrospective cross-sectional study.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Association between triglyceride-glucose-related indices and liver-related events in patients with type 2 diabetes.Frontiers in endocrinology · 2026Article
- Association of triglyceride-glucose index and remnant cholesterol levels with liver fibrosis progression and disease severity in patients with non-alcoholic fatty liver disease: a cross-sectional study.Frontiers in endocrinology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious research has established an association between insulin resistance with alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Studies examining the association between insulin resistance and these enzymes in metabolic syndrome, as determined by the triglyceride-glucose (TyG) index, are scarce. This research aims to investigate the relationship between the TyG index and liver enzyme levels in individuals diagnosed with metabolic syndrome. MATERIALS AND
methodsThis study was conducted in tertiary care hospitals among the Indian adult population aged 20 to 70 who came for regular health checkups at health checkup units from 2021 to 2022. In total, 12112 data were retrieved from the medical record department. After removing the data that didn't meet our inclusion criteria, 896 participants with metabolic syndrome, 384 females and 512 males, were enrolled.
resultsSignificant differences in AST, ALT, and ALT/AST ratio were observed across TyG index tertiles (
conclusionThe TyG index, a simple and inexpensive metric derived from commonly performed laboratory tests, may be a valuable predictor of abnormal liver enzymes (ALT, AST) and their ratio (ALT/AST) in metabolic syndrome patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.