Evidence map›Paper›PMID 40579839›Full record

ArticleJournal of neuroscience research2025

Lanthionine Ketimine Ethyl Ester Induces Proliferation and Maturation and Regulates Calcium Flux in Primary Mouse Oligodendrocyte Progenitor Cells.

Veronica T Cheli, Swathi G Tumuluri, Zachary McDonald, Travis T Denton, Jeffrey L Dupree, Pablo M Paez, Douglas L Feinstein

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroscience research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Veronica T CheliInstitute for Myelin and Glia Exploration, Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, New York, USA.
Swathi G TumuluriInstitute for Myelin and Glia Exploration, Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, New York, USA.
Zachary McDonaldDepartment Anesthesiology, University of Illinois, Chicago, Illinois, USA.
Travis T DentonDepartment of Pharmaceutical Sciences, College of Pharmacy & Pharmaceutical Sciences, Washington State University Health Sciences Spokane, Spokane, Washington, USA.ORCID https://orcid.org/0000-0002-1222-2538
Jeffrey L DupreeDepartment of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, Virginia, USA.ORCID https://orcid.org/0000-0002-6235-570X
Pablo M PaezInstitute for Myelin and Glia Exploration, Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, New York, USA.ORCID https://orcid.org/0000-0001-9362-9454
Douglas L FeinsteinDepartment Anesthesiology, University of Illinois, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0003-2815-2885

Funding

Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
National Multiple Sclerosis SocietyNIEHS NIH HHS P30 ES027792U.S. Department of Veterans AffairsWashington Research Foundation
6 · The paper itself

Abstract

Previous studies have shown that lanthionine ketimine ethyl ester (LKE), a semi-synthetic derivative of the endogenous amino acid lanthionine, can induce proliferation and maturation of oligodendrocyte progenitor cells (OPCs) in vivo. In the current study, we examined the effects of LKE on Ca

Indexed as

AlanineCalciumCell DifferentiationCell ProliferationOligodendrocyte Precursor CellsSulfidesAmino Acids, SulfurAnimalsCells, CulturedIntercellular Signaling Peptides and ProteinsMiceMice, Inbred C57BLNerve Tissue ProteinsAlanineAmino Acids, SulfurCalciumcollapsin response mediator protein-2Intercellular Signaling Peptides and Proteinslanthionine ketimineNerve Tissue ProteinsSulfidescalcium channelscalcium imaginglanthioninemyelinNMDA receptorsoligodendrocyte

Identifiers

PMID40579839
PMCPMC12205228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.