ArticleThe Journal of small animal practice2025
Weekly biological variation of serum biochemistry analytes and fibroblast growth factor 23 in healthy cats and cats with chronic kidney disease.
Article in The Journal of small animal practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
objectiveThe objective of the study was to determine the biological variation of select serum biochemistry analytes and fibroblast growth factor 23 in both clinically healthy cats and cats with chronic kidney disease.
methodsEleven healthy cats and seven cats with chronic kidney disease International Renal Interest Society Stages 2 and 3 were included. Sera were collected once a week for 6 weeks and frozen for batch analysis in duplicate. Blood urea nitrogen, total carbon dioxide, creatinine, magnesium, phosphate, potassium, symmetric dimethylarginine, total calcium and fibroblast growth factor 23 were measured. Restricted maximum likelihood estimations were used to determine the coefficients of variation, and the inverse indices of individuality and reference change values were calculated.
resultsNo analytes had low individuality. Biochemistry analytes had either intermediate or high individuality in healthy cats and cats with chronic kidney disease. Fibroblast growth factor 23 had high individuality in healthy cats and cats with chronic kidney disease. The reference change values for analytes was overall similar between healthy cats and cats with chronic kidney disease, including the reference change values for creatinine (19.8% and 18.4%, respectively), symmetric dimethylarginine (35.2% and 35.5%, respectively) and fibroblast growth factor 23 (60.0% and 75.5%, respectively). CLINICAL SIGNIFICANCE: Biological variation estimates for each analyte were similar between healthy cats and those with chronic kidney disease. All analytes had intermediate to high individuality in cats with chronic kidney disease; thus, determining a cat's baseline and applying the reference change values to subsequent measurements may enhance the detection of clinically relevant changes that could be missed when using population-based reference intervals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.