Evidence map›Paper›PMID 40579785›Full record

ReviewClinical and translational medicine2025

Decoding the pancreatic cancer microenvironment: The multifaceted regulation of microRNAs.

Jie Ji, Dandan Jin, Junpeng Zhao, Xudong Xie, Yujie Jiao, Xuyang He, Yuxuan Huang, Lirong Zhou, Mingbing Xiao, Xiaolei Cao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical and translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jie JiDepartment of Gastroenterology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China.
Dandan JinDepartment of Gastroenterology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China.
Junpeng ZhaoDepartment of Gastroenterology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China.
Xudong XieDepartment of Gastroenterology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China.
Yujie JiaoDepartment of Gastroenterology, Affiliated Changshu Hospital of Nantong University, Changshu, Jiangsu, China.
Xuyang HeDepartment of Clinical Medicine, Medical School of Nantong University, Nantong, Jiangsu, China.
Yuxuan HuangDepartment of Clinical Medicine, Medical School of Nantong University, Nantong, Jiangsu, China.
Lirong ZhouDepartment of Clinical Medicine, Medical School of Nantong University, Nantong, Jiangsu, China.
Mingbing XiaoDepartment of Gastroenterology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China.
Xiaolei CaoDepartment of Pathology, Medical School of Nantong University, Nantong, Jiangsu, China.ORCID 0000-0003-3372-1069

Funding

Jiangsu Provincial Medical Key Discipline ZDXK202240Jiangsu Provincial Research Hospital YJXYY202204National Natural Science Foundation of China 82272624National Natural Science Foundation of China 82471851'Revitalize Project in Science and Education of Department of Public Health' Youth Science and Technology Project KJXW2021069Special Project for Prospective Technology Innovation Z2024007the China Postdoctoral Science Foundation 2024M751536the Health Project of Nantong City MS2023009the Key Research and Development Project of Nantong Citythe Postgraduate Research and Practice Innovation Program of Jiangsu Province KYCX23_3419the Postgraduate Research and Practice Innovation Program of Jiangsu Province KYCX24_3593the Social Development Foundation of Nantong City MS2023086
6 · The paper itself

Abstract

Pancreatic cancer (PC) is an extremely deadly type of cancer, and the 5-year survival rate remains less than 10%. The tumour microenvironment (TME) affects the occurrence, progression and treatment outcomes of PC. MicroRNAs (miRNAs) are essential to regulate PC TME. This review delves into the different roles of miRNAs in the PC TME, including exosome communication, angiogenesis, interactions with cancer-associated fibroblasts, the immunological and neuronal microenvironments and metabolic reprogramming. However, research on the complex regulatory networks and synergistic effects of miRNAs in the TME is still insufficient, and their clinical translation and application face challenges. This review summarised the activities of miRNAs in the PC TME, guiding future research and therapeutic strategies involving miRNAs in PC. Future studies should integrate advanced technologies to decode the spatiotemporal dynamics of miRNA regulation within the TME and develop optimised nanodelivery systems for stable and targeted miRNA delivery, advancing clinical applications in PC treatment.

Indexed as

MicroRNAsPancreatic NeoplasmsTumor MicroenvironmentHumansMicroRNAsexosomeimmune microenvironmentmiRNAPCtumour microenvironment

Identifiers

PMID40579785
PMCPMC12205012

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.