ArticlePest management science2025
The serine palmitoyl transferase of plant pathogenic fungi: a promising new target for the development of novel crop protection solutions
Article in Pest management science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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14 authors.
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Abstract
backgroundPlant pathogens pose a significant threat to global agriculture and, thus to world food supplies, requiring the development of fungicides with new modes of action. Pyridazine carboxamides (PCs) represent a novel class of fungicides that inhibit serine palmitoyl transferase (SPT), an enzyme crucial for sphingolipid biosynthesis in fungi. The efficacy and the mechanism of action of PCs is explored in this study, highlighting their potential as a new fungicidal compound class effective on a wide range of Ascomycota pathogen.
resultsPCs demonstrate a strong biological efficacy against a broad range of Ascomycetes in in vitro and in planta assays, although they are less effective against the wheat pathogen Zymoseptoria tritici. PC resistant ultraviolet (UV)-mutants of Botrytis cinerea exhibit mutations in the LCB2 subunit of SPT, indicating that SPT is the target enzyme for this class of compounds. Treatment of fungal cells with PCs reduced sphingolipid level, and enzymatic assays revealed that SPT from both B. cinerea and Z. tritici were highly sensitive to PCs. Finally, supplementation with phytosphingosine reversed the fungicidal activity of PCs, confirming that SPT inhibition is the mechanism of action.
conclusionThe discovery and validation of PCs as effective SPT inhibitors provide a novel mode of action group to control plant pathogens and offer a potential future tool to manage resistance risks in the fields. Further exploration of this chemical class and target can help in creating innovative solutions to safeguard agricultural productivity and food security worldwide. © 2025 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
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