ArticleMicrocirculation (New York, N.Y. : 1994)2025
Modulatory Role of Nitric Oxide on the Vasomotor Actions of NPY in Porcine Cerebral Arteries.
Article in Microcirculation (New York, N.Y. : 1994), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Modulatory Role of Nitric Oxide on the Vasomotor Actions of NPY in Porcine Cerebral Arteries.Microcirculation (New York, N.Y. : 1994) · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
Neuropeptide Y (NPY) is a sympathetic co-transmitter that mediates vasoconstriction. However, there is evidence that it may also mediate dilation through a nitric oxide (NO)-dependent mechanism.
objectiveWe used a swine model to examine how NPY influences cerebral vascular regulation and hypothesized that NPY would elicit both vasoconstrictor and vasodilatory effects, and that such effects would be modulated partially by NO signaling.
methodsBriefly, cerebral perfusion and blood pressure were monitored during intracarotid saline or NPY infusion (0.1 μg/kg) in the presence and absence of NO synthase (NOS) inhibition (N
resultsIntracarotid NPY infusions elicited transient dilation that was blocked by NOS inhibition. In isolated pial arteries, distinct populations of NPY-Y1 receptors were observed on both the vascular smooth muscle (VSM) and endothelium. Extraluminal application of NPY elicited vasoconstriction, while intraluminal delivery elicited vasodilation. NOS inhibition enhanced the magnitude of vasoconstriction in isolated pial arteries. Endothelial denudation, Y1 receptor antagonism, and NOS inhibition each blunted NPY-induced vasodilation.
conclusionThese data suggest both vasoconstrictor and vasodilatory effects of NPY are modulated partially by NO signaling.
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