ArticleBMC geriatrics2025
Prevalence of frailty among older patients with acute ischemic stroke and its association with short-term functional outcome: a cohort study in Vietnam.
Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Principal Component-Based Comprehensive Physical Health Score Associates With Long-Term Death in Patients With Ischemic Stroke.Journal of the American Heart Association · 2026Article
- Prediction model for frailty risk in ischemic stroke patients: Application and validation of support vector machines and nomograms.Medicine · 2026Article
- Primary and Secondary Prevention of Ischemic Stroke in Elderly Patients with Cardiovascular Disease: The Role of Frailty and Care Pathways.Neurology international · 2026Review
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Authors and funding
5 authors.
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Abstract
backgroundAmong older adults with acute illnesses, frailty is common and strongly associated with poorer prognosis. This study aimed to investigate the prevalence of pre-stroke frailty and its association with short-term functional outcomes in older patients with acute ischemic stroke (AIS).
methodsWe included consecutive AIS patients aged ≥ 60 years admitted to a hospital in Vietnam. Pre-stroke frailty was assessed using the modified Short Emergency Geriatric Assessment (mSEGA) frailty scale (score 0-8: not frail; score 9-11: frail; score 12-26: very frail). Short-term functional outcomes were evaluated using the modified Rankin Scale (mRS) at 30 days based on follow-up clinical assessments and interviews, with poor outcomes defined as mRS ≥ 3. The association between pre-stroke frailty and stroke outcomes was assessed using multivariable logistic regression analysis.
resultsA total of 304 participants (61.5% with mild and 38.5% with moderate stroke) were included, with a mean age of 78.0 ± 8.5 years, and 57.6% were female. The prevalence of pre-stroke frailty and very frailty was 30.6% and 32.2%, respectively. Multivariable logistic regression analysis demonstrated that pre-stroke very frail status remained an independent predictor of poor functional outcomes at 30 days, with an adjusted odds ratio (OR) of 3.29 (95% CI: 1.45-7.46, p = 0.004), after adjustment for age, sex, baseline NIHSS, and treatment strategy.
conclusionsThis study revealed a high prevalence of pre-stroke frailty among older patients with AIS in Vietnam. Pre-stroke very frail status was significantly associated with an increased risk of poor functional outcomes in this population.
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