Evidence map›Paper›PMID 40579647›Full record

ArticleMolecular neurobiology2025

Macluraparishin C Enhances Neuroprotection Against Oxidative Stress-Induced Neurodegeneration by Activating the Antioxidant/MAPK Signaling Pathway.

Md Shiblee Sadik Sabuj, Md Sadikul Islam, Md Rashedunnabi Akanda, Joonseok Lee, Ryunhee Kim, Seung Hyun Lee, Ye Ji Kim, Jin Min Oh, Hyeon Gyeong Ro, In-Shik Kim and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Synergistic Effects of Anthocyanin-EnrichedFoods (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Md Shiblee Sadik SabujCollege of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, 54596, South Korea.
Md Sadikul IslamCollege of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, 54596, South Korea.
Md Rashedunnabi AkandaDepartment of Pharmacology and Toxicology, Sylhet Agricultural University, Sylhet, 3100, Bangladesh.
Joonseok LeeCollege of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, 54596, South Korea.
Ryunhee KimCollege of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, 54596, South Korea.
Seung Hyun LeeCollege of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, 54596, South Korea.
Ye Ji KimCollege of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, 54596, South Korea.
Jin Min OhCollege of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, 54596, South Korea.
Hyeon Gyeong RoCollege of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, 54596, South Korea.
In-Shik KimCollege of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, 54596, South Korea.
Dongchoon AhnCollege of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, 54596, South Korea.
Sang-Youel ParkCollege of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, 54596, South Korea.
Hyun-Jin TaeCollege of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, 54596, South Korea. hjtae@jbnu.ac.kr.
Byung-Yong ParkCollege of Veterinary Medicine and Institute of Animal Transplantation, Jeonbuk National University, Iksan, 54596, South Korea. parkb@jbnu.ac.kr.

Funding

Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry (IPET), South Korea RS-2022-IP322087National Research Foundation of Korea (NRF), South korea RS-2023-00247813
6 · The paper itself

Abstract

Oxidative stress plays a critical role in the development and progression of neurodegenerative diseases through the induction of neuronal injury and apoptosis. Macluraparishin C (MPC) is a novel parishin compound with identified potent neuroprotection, whose molecular mechanisms have not been clarified yet. The present research aims to explore the neuroprotective function of MPC in the context of the bilateral common carotid artery (BCCA) occlusion-induced transient global cerebral ischemia (tGCI) in gerbils, along with hydrogen peroxide (H

Indexed as

AntioxidantsDrugs, Chinese HerbalMAP Kinase Signaling SystemNerve DegenerationNeuroprotectionNeuroprotective AgentsOxidative StressAnimalsCell Line, TumorCell SurvivalGerbillinaeHumansHydrogen PeroxideMaleNeuronsAntioxidantsDrugs, Chinese HerbalHydrogen PeroxideNeuroprotective AgentsAntioxidantMacluraparishin CMAPKNeurodegenerationOxidative stressTransient global cerebral ischemia

Identifiers

PMID40579647
PMCPMC12433353

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.