Evidence map›Paper›PMID 40579620›Full record

ArticleNature metabolism2025

Dietary control of peripheral adipose storage capacity through membrane lipid remodelling.

Marcus J Tol, Yuta Shimanaka, Alexander H Bedard, Jennifer Sapia, Liujuan Cui, Mariana Colaço-Gaspar, Peter Hofer, Alessandra Ferrari, Kevin Qian, John P Kennelly and 20 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

30 authors.

Marcus J Tol *Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA, USA.
Yuta Shimanaka *Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-2333-0091
Alexander H BedardDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, CA, USA.
Jennifer SapiaDepartment of Biology, University of Fribourg, Fribourg, Switzerland.ORCID http://orcid.org/0009-0004-8681-7085
Liujuan CuiDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-6186-1558
Mariana Colaço-GasparInstitute of Molecular Biosciences, University of Graz, Graz, Austria.ORCID http://orcid.org/0000-0003-2297-7798
Peter HoferInstitute of Molecular Biosciences, University of Graz, Graz, Austria.
Alessandra FerrariDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-7354-9895
Kevin QianDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, CA, USA.
John P KennellyDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-4399-3976
Stephen D LeeDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-4663-9534
Yajing GaoDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-8836-4452
Xu XiaoDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, CA, USA.
Jie GaoDepartment of Neuroscience, The Ohio State University, Wexner Medical Center, Columbus, OH, USA.ORCID http://orcid.org/0000-0001-5448-6606
Julia J MackMolecular Biology Institute, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-9239-8436
Thomas A WestonDepartment of Medicine, Division of Cardiology, University of California, Los Angeles, CA, USA.
Kevin J WilliamsDepartment of Biological Chemistry, University of California, Los Angeles, CA, USA.
Baolong SuDepartment of Biological Chemistry, University of California, Los Angeles, CA, USA.
Calvin PanDepartment of Medicine, Division of Cardiology, University of California, Los Angeles, CA, USA.
Aldons J LusisDepartment of Medicine, Division of Cardiology, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-9013-0228
Daniel P PikeEdward A. Doisy Department of Biochemistry and Molecular Biology, and Center for Cardiovascular Research, Saint Louis University School of Medicine, St. Louis, MO, USA.
Alex ReedDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
Natalia MilosevichDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
Benjamin F CravattDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-5330-3492
Makoto AritaDivision of Physiological Chemistry and Metabolism, Graduate School of Pharmaceutical Sciences, Keio University, Tokyo, Japan.ORCID http://orcid.org/0000-0001-9902-0463
Stephen G YoungDepartment of Medicine, Division of Cardiology, University of California, Los Angeles, CA, USA.
David A FordEdward A. Doisy Department of Biochemistry and Molecular Biology, and Center for Cardiovascular Research, Saint Louis University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-0029-1560
Rudolf ZechnerInstitute of Molecular Biosciences, University of Graz, Graz, Austria.
Stefano VanniDepartment of Biology, University of Fribourg, Fribourg, Switzerland.ORCID http://orcid.org/0000-0003-2146-1140
Peter TontonozDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, CA, USA. PTontonoz@mednet.ucla.edu.ORCID http://orcid.org/0000-0003-1259-0477

Funding

Investigating Mechanisms for Lipid Transport in Health and DiseaseR35HL139725 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2018 to 2024
$6.1M
Membrane homeostasis in adipose physiology and obesityR01DK129276 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TONTONOZ, PETER J · 2021 to 2024
$1.9M
NHLBI NIH HHS R35 HL139725NIDDK NIH HHS R01 DK129276U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK129276
6 · The paper itself

Abstract

Genetic and dietary cues are known drivers of obesity, yet how they converge at the molecular level is incompletely understood. Here we show that PPARγ supports hypertrophic expansion of adipose tissue via transcriptional control of LPCAT3, an endoplasmic reticulum (ER)-resident O-acyltransferase that selectively enriches diet-derived omega-6 polyunsaturated fatty acids (n-6 PUFAs) in the membrane lipidome. In mice fed a high-fat diet, lowering membrane n-6 PUFA levels through genetic or dietary interventions results in aberrant adipose triglyceride (TG) turnover, ectopic fat deposition and insulin resistance. Additionally, we detail a non-canonical adaptive response in 'lipodystrophic' Lpcat3

Indexed as

Adipose TissueMembrane Lipids1-Acylglycerophosphocholine O-AcyltransferaseAdipocytesAnimalsDiet, High-FatEndoplasmic ReticulumInsulin ResistanceLipid MetabolismMaleMiceMice, Inbred C57BLMice, KnockoutObesityPPAR gammaTriglycerides1-Acylglycerophosphocholine O-AcyltransferaseLPCAT3 protein, mouseMembrane LipidsPPAR gammaTriglycerides

Identifiers

PMID40579620

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.